{"product_id":"recombinant-human-t-cell-surface-glycoprotein-cd8-alpha-and-beta-heterodimer-protein-cd8a-and-cd8b-bhp10516993","title":"Recombinant Human T-cell surface glycoprotein CD8 alpha\u0026beta Heterodimer Protein (CD8A\u0026CD8B)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eThis product is a recombinant human CD8A\u0026amp;CD8B protein commonly used as a defined reagent for assay development, interaction studies, and cell-based functional experiments. \u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eExpression region:\u003c\/strong\u003e 1-182aa\u0026amp;22-170aa — region selection can affect binding epitopes and functional interpretation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eExpression system:\u003c\/strong\u003e Mammalian cell — expression context can influence folding and post-translational features.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/format:\u003c\/strong\u003e C-terminal 10xHis-tagged\u0026amp;C-terminal Twin-Strep-tagged — useful for platform-specific capture or detection workflows.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eCD8A\u0026amp;CD8B is studied for its biological roles within relevant pathways and cellular contexts. Recombinant reagents enable controlled dosing and binding measurements independent of endogenous expression.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eAssay development that combines purified proteins with cell-based readouts for cross-validation.\u003c\/li\u003e \u003cli\u003eDomain- and isoform-aware studies to interpret binding specificity and functional outcomes.\u003c\/li\u003e \u003cli\u003eIntegration of recombinant proteins into multi-omics workflows for pathway characterization.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eUse as a reagent for consistent dosing across in vitro assays\u003c\/li\u003e \u003cli\u003eGenerate standard curves or spike-in controls in buffer or sample matrix for plate assays\u003c\/li\u003e \u003cli\u003eProfile protein–protein interactions involving CD8A\u0026amp;CD8B using pull-down or co-binding assays\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eConsider isoforms, processing, or post-translational modifications that may differ from endogenous protein across systems.\u003c\/li\u003e \u003cli\u003eFor tagged or labeled formats, confirm that the tag does not occlude binding sites relevant to your readout.\u003c\/li\u003e \u003cli\u003eUse appropriate negative\/positive controls and orthogonal assays when interpreting binding or activity differences.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt Knowledgebase (UniProt): https:\/\/www.uniprot.org\/ - NCBI Gene (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - NCBI Protein (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/protein\/ - Reactome Pathway Database: https:\/\/reactome.org\/ - KEGG Pathway Database: https:\/\/www.kegg.jp\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53059855352173,"sku":"CSB-MP6900HU-1MG","price":2800.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53059920134509,"sku":"CSB-MP6900HU-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53059920167277,"sku":"CSB-MP6900HU-20UG","price":190.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-MP6900HU-SDS.jpg?v=1772294701","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-t-cell-surface-glycoprotein-cd8-alpha-and-beta-heterodimer-protein-cd8a-and-cd8b-bhp10516993","provider":"BioHippo","version":"1.0","type":"link"}