{"product_id":"recombinant-human-t-lymphocyte-activation-antigen-cd80-cd80-partial-bhp10506553","title":"Recombinant Human T-lymphocyte activation antigen CD80 (CD80), partial","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003eCD80\u003c\/strong\u003e from Homo sapiens (Human), produced in Mammalian cell (region 35-242aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 35-242aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e Mammalian cell (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e Myc (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as Activation B7-1 antigen (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD80) (CD28LG) (CD28LG1) (LAB7). Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eQuantitative mapping of ligand\/receptor signaling to downstream phospho- and transcriptional programs.\u003c\/li\u003e\n\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInvolved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.Acts as a receptor for adenovirus subgroup B.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving CD80\u003c\/li\u003e\n\u003cli\u003eBinding interaction studies (e.g., SPR\/BLI or plate-based binding formats)\u003c\/li\u003e\n\u003cli\u003eCell-based stimulation studies with downstream marker readouts (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB P33681 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P33681 - NCBI Gene search: CD80 — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CD80 - Ensembl search: CD80 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CD80 - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053387178349,"sku":"CSB-MP004959HU1-1MG","price":1902.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053495869805,"sku":"CSB-MP004959HU1-100UG","price":254.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53053495902573,"sku":"CSB-MP004959HU1-20UG","price":102.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-MP004959HU1-SDS.jpg?v=1772177578","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-t-lymphocyte-activation-antigen-cd80-cd80-partial-bhp10506553","provider":"BioHippo","version":"1.0","type":"link"}