{"product_id":"recombinant-human-thyroid-stimulating-hormone-bhp11006479","title":"Recombinant Human Thyroid Stimulating Hormone","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Thyroid Stimulating Hormone\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eThyroid-stimulating hormone (TSH), also known as thyrotropin, is a glycoprotein hormone produced by the anterior pituitary gland. Its primary function is to regulate thyroid gland activity by stimulating the synthesis and secretion of thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Recombinant human TSH (rhTSH) has emerged as a valuable tool in clinical practice, particularly in the management of thyroid disorders and in diagnostic procedures involving the thyroid gland. This paper aims to provide an overview of research on rhTSH, including its mechanism of action, activity, and therapeutic applications. The mechanism of action of rhTSH involves binding to the TSH receptor (TSHR) on the surface of thyroid follicular cells. This interaction activates intracellular signalling pathways, including cyclic adenosine monophosphate (cAMP) production and protein kinase A (PKA) activation. These pathways stimulate various cellular processes within thyroid follicular cells, such as iodine uptake, thyroid hormone synthesis, and secretion.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"100 mIU","offer_id":53038187938157,"sku":"hor-050-100MIU","price":300.0,"currency_code":"USD","in_stock":true},{"title":"500 mIU","offer_id":53038563361133,"sku":"hor-050-500MIU","price":800.0,"currency_code":"USD","in_stock":true},{"title":"1000 mIU","offer_id":53038563393901,"sku":"hor-050-1000MIU","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-tsh-recombinant-HOR-050.png?v=1782158402","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-thyroid-stimulating-hormone-bhp11006479","provider":"BioHippo","version":"1.0","type":"link"}