{"product_id":"recombinant-human-tissue-type-plasminogen-activator-plat-r497q-bhp10508115","title":"Recombinant Human Tissue-type plasminogen activator (PLAT) (R497Q)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003ePLAT\u003c\/strong\u003e from Homo sapiens (Human), produced in Baculovirus (region 36-562aa(R497Q)). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 36-562aa(R497Q) (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e Baculovirus (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e His, Myc (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as INN: Alteplase INN: Reteplase. Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eConverts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving PLAT\u003c\/li\u003e\n\u003cli\u003eBinding and specificity benchmarking for detection reagents (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB P00750 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P00750 - NCBI Gene search: PLAT — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PLAT - Ensembl search: PLAT — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PLAT - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053434397037,"sku":"CSB-BP018120HU(A4)(M1)-1MG","price":2240.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053590110573,"sku":"CSB-BP018120HU(A4)(M1)-100UG","price":887.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53053590143341,"sku":"CSB-BP018120HU(A4)(M1)-20UG","price":317.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-BP018120HU_A4_M1_-SDS.jpg?v=1772177749","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-tissue-type-plasminogen-activator-plat-r497q-bhp10508115","provider":"BioHippo","version":"1.0","type":"link"}