{"product_id":"recombinant-human-tnf-ligand-superfamily-member-12-bhp11000804","title":"Recombinant Human TNF Ligand Superfamily Member 12","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human TNF Ligand Superfamily Member 12\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eTNFSF12 is a cytokine that is part of the TNF ligand family. TNFSF12 is a ligand for the FN14\/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TNFSF12 induces apoptosis through multiple pathways of cell death in a cell type-specific manner. TNFSF12 promotes proliferation and migration of endothelial cells, and therefore acts as a regulator of angiogenesis. TNFSF12 is expressed in adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK h induces NFkB and chemokine secretion. TNFSF12 exerts an apoptotic activity in HT-29 human adenocarcinoma cells whilst cultured in the presence of IFN-?. TNFSF12 promotes proliferation and migration of endothelial cells.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038062338413,"sku":"cyt-699-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25 ug","offer_id":53038308524397,"sku":"cyt-699-25UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038308557165,"sku":"cyt-699-1MG","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-tnfsf12-human-CYT-699.png?v=1782158153","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-tnf-ligand-superfamily-member-12-bhp11000804","provider":"BioHippo","version":"1.0","type":"link"}