{"product_id":"recombinant-human-tumor-necrosis-factor-receptor-superfamily-member-9-tnfrsf9-partial-active-bhp10506376","title":"Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003eTNFRSF9\u003c\/strong\u003e from Homo sapiens (Human), produced in Mammalian cell (region 24-186aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 24-186aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e Mammalian cell (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e His, Fc (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as CD137;ILA;TNFRSF9;4-1BB ligand receptor;CDw137;T-cell antigen 4-1BB homolog;T-cell antigen ILA. Receptor for TNFSF9\/4-1BBL. Possibly active during T cell activation.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eQuantitative mapping of ligand\/receptor signaling to downstream phospho- and transcriptional programs.\u003c\/li\u003e\n\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eTumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9\/4-1BBL, and possibly active during T cell activation.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving TNFRSF9\u003c\/li\u003e\n\u003cli\u003eBinding interaction studies (e.g., SPR\/BLI or plate-based binding formats)\u003c\/li\u003e\n\u003cli\u003eCell-based stimulation studies with downstream marker readouts (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB Q07011 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q07011 - NCBI Gene search: TNFRSF9 — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TNFRSF9 - Ensembl search: TNFRSF9 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TNFRSF9 - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053382394221,"sku":"CSB-AP005131HU-1MG","price":4060.0,"currency_code":"USD","in_stock":true},{"title":"500 ug","offer_id":53053487481197,"sku":"CSB-AP005131HU-500UG","price":2514.0,"currency_code":"USD","in_stock":true},{"title":"50 ug","offer_id":53053487513965,"sku":"CSB-AP005131HU-50UG","price":406.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-AP005131HU.jpg?v=1772177560","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-tumor-necrosis-factor-receptor-superfamily-member-9-tnfrsf9-partial-active-bhp10506376","provider":"BioHippo","version":"1.0","type":"link"}