{"product_id":"recombinant-human-voltage-dependent-calcium-channel-subunit-alpha-2-delta-1-cacna2d1-partial-bhp10506925","title":"Recombinant Human Voltage-dependent calcium channel subunit alpha-2\/delta-1 (CACNA2D1), partial","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003eCACNA2D1\u003c\/strong\u003e from Homo sapiens (Human), produced in E.coli (region 528-668aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 528-668aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e E.coli (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e His, SUMO (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as Voltage-gated calcium channel subunit alpha-2\/delta-1. The alpha-2\/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation\/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eThe alpha-2\/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation\/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving CACNA2D1\u003c\/li\u003e\n\u003cli\u003eBinding and specificity benchmarking for detection reagents (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB P54289 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P54289 - NCBI Gene search: CACNA2D1 — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CACNA2D1 - Ensembl search: CACNA2D1 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CACNA2D1 - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053397467501,"sku":"CSB-EP004407HU-1MG","price":1812.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053515432301,"sku":"CSB-EP004407HU-100UG","price":419.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53053515465069,"sku":"CSB-EP004407HU-20UG","price":224.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-EP004407HU-SDS.jpg?v=1772177614","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-voltage-dependent-calcium-channel-subunit-alpha-2-delta-1-cacna2d1-partial-bhp10506925","provider":"BioHippo","version":"1.0","type":"link"}