{"product_id":"recombinant-i-tac-cxcl11-human-bhp11300102","title":"Recombinant I-TAC\/CXCL11,Human","description":"\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600;margin-right:8px}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eI-TAC (Interferon-inducible T-cell α Chemoattractant), also known as CXCL11, is a chemokine belonging to the CXCL subfamily. Along with Interferon-γ induced Protein 10 kDa and Monokine Induced by Interferon-γ, I-TAC is strongly up-regulated by Interferon-γ and binds to the G-protein coupled receptor CXCR3. The expression of CXCR3 is associated with Th1-mediated immune responses and mediates chemotaxis of Th1 cells. I-TAC induces, maintains, and amplifies the inflammatory reactions, and sustains chronic immune responses against self-antigens.\u003c\/p\u003e\n\n\u003ch2\u003eProduct Description\u003c\/h2\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eE. coli Expression\u003c\/span\u003e\n\u003cp\u003eRecombinant I-TAC\/CXCL11 Human protein is produced using a validated E. coli expression system and supplied as lyophilized powder for long-term stability. Suitable for use in functional bioassays, ELISA standard curves, receptor binding studies, antibody validation, and related research applications.\u003c\/p\u003e\n\n\u003ch2\u003eProtein Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n  \u003ctr\u003e\n\u003cth\u003eExpression System\u003c\/th\u003e\n\u003ctd\u003eE. coli\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e8.4 kDa, observed by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e\u0026gt; 95% as analyzed by SDS-PAGE and HPLC.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eEndotoxin\u003c\/th\u003e\n\u003ctd\u003e\u0026lt; 0.2 EU\/μg, determined by LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003ePhysical Form\u003c\/th\u003e\n\u003ctd\u003eSterile Filtered White lyophilized (freeze-dried) powder.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eFormulation\u003c\/th\u003e\n\u003ctd\u003eLyophilized after extensive dialysis against PBS.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eReconstitution\u003c\/th\u003e\n\u003ctd\u003eReconstituted in ddH2O at 100 μg\/mL.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eLyophilized recombinant human I-TAC\/CXCL11 (rhI-TAC) remains stable up to 6 months at -80°C from dat…\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\n\u003cdiv class=\"bhp-qc-badge\"\u003e✓ Purity Verified by SDS-PAGE\u003c\/div\u003e \u003cdiv class=\"bhp-qc-badge\"\u003e✓ LAL Endotoxin-Tested\u003c\/div\u003e\n\n\u003ch2\u003eFunctional Activity\u003c\/h2\u003e\n\u003cp\u003eED50 \u0026lt; 2.5 µg\/mL, measured by the FLIPR assay using CHO cells transfected with human CXCR3, the receptor of human CXCL11, corresponding to a specific activity of \u0026gt; 400 units\/mg.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003eThis material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Bioworld Technology Inc","offers":[{"title":"10 ug","offer_id":53326139326829,"sku":"BK0114-10UG","price":132.0,"currency_code":"USD","in_stock":true},{"title":"50 ug","offer_id":53326161543533,"sku":"BK0114-50UG","price":420.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53326161576301,"sku":"BK0114-1MG","price":2200.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/recombinant-i-tac-cxcl11-human-bhp11300102","provider":"BioHippo","version":"1.0","type":"link"}