{"product_id":"recombinant-mesocricetus-auratus-programmed-cell-death-1-ligand-1-cd274-partial-biotinylated-bhp10517016","title":"Recombinant Mesocricetus auratus Programmed cell death 1 ligand 1 (Cd274), partial, Biotinylated","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eThis product is a recombinant golden hamster Cd274 protein commonly used as a defined reagent for assay development, interaction studies, and cell-based functional experiments. \u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eExpression region:\u003c\/strong\u003e 20-238aa — region selection can affect binding epitopes and functional interpretation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eExpression system:\u003c\/strong\u003e Mammalian cell — expression context can influence folding and post-translational features.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/format:\u003c\/strong\u003e C-terminal 6xHis-Avi-tagged — useful for platform-specific capture or detection workflows.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat note:\u003c\/strong\u003e Labeled as biotinylated in the product title; confirm compatibility with your assay design.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eThe PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1\/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eBiomarker and signaling studies that connect target abundance to tumor phenotypes.\u003c\/li\u003e \u003cli\u003eMapping protein–protein interactions that regulate proliferation, migration, or immunity.\u003c\/li\u003e \u003cli\u003eAssay development for screening pathway modulators in relevant cancer models.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eUse as a reagent for consistent dosing across in vitro assays\u003c\/li\u003e \u003cli\u003eGenerate standard curves or spike-in controls in buffer or sample matrix for plate assays\u003c\/li\u003e \u003cli\u003eProfile protein–protein interactions involving Cd274 using pull-down or co-binding assays\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eConsider isoforms, processing, or post-translational modifications that may differ from endogenous protein across systems.\u003c\/li\u003e \u003cli\u003eFor tagged or labeled formats, confirm that the tag does not occlude binding sites relevant to your readout.\u003c\/li\u003e \u003cli\u003eUse appropriate negative\/positive controls and orthogonal assays when interpreting binding or activity differences.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt Knowledgebase (UniProt): https:\/\/www.uniprot.org\/ - NCBI Gene (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - NCBI Protein (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/protein\/ - Reactome Pathway Database: https:\/\/reactome.org\/ - KEGG Pathway Database: https:\/\/www.kegg.jp\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53059856466285,"sku":"CSB-MP7255MRG-B-1MG","price":2988.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53059921183085,"sku":"CSB-MP7255MRG-B-100UG","price":412.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53059921215853,"sku":"CSB-MP7255MRG-B-20UG","price":166.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-MP7255MRG-B-SDS.jpg?v=1772294625","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-mesocricetus-auratus-programmed-cell-death-1-ligand-1-cd274-partial-biotinylated-bhp10517016","provider":"BioHippo","version":"1.0","type":"link"}