{"product_id":"recombinant-mouse-c-type-lectin-domain-family-4-member-k-cd207-partial-bhp10507737","title":"Recombinant Mouse C-type lectin domain family 4 member K (Cd207), partial","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003eCd207\u003c\/strong\u003e from Mus musculus (Mouse), produced in Mammalian cell (region 63-331aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 63-331aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e Mammalian cell (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e His (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as Langerin (CD_antigen: CD207) (Clec4k). Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules; is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate and beta-glucans. Facilitates uptake of antigens and is involved in the routing and\/or processing of antigen for presentation to T cells.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eCalcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules; is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate and beta-glucans. Facilitates uptake of antigens and is involved in the routing and\/or processing of antigen for presentation to T cells.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving Cd207\u003c\/li\u003e\n\u003cli\u003eBinding and specificity benchmarking for detection reagents (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB Q8VBX4 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q8VBX4 - NCBI Gene search: Cd207 — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Cd207 - Ensembl search: Cd207 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Cd207 - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053421551981,"sku":"CSB-MP837695MO-1MG","price":3168.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053565665645,"sku":"CSB-MP837695MO-100UG","price":448.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53053565698413,"sku":"CSB-MP837695MO-20UG","price":256.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-MP837695MO-SDS.jpg?v=1772177703","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-mouse-c-type-lectin-domain-family-4-member-k-cd207-partial-bhp10507737","provider":"BioHippo","version":"1.0","type":"link"}