{"product_id":"recombinant-mouse-dickkopf-related-protein-1-bhp11006088","title":"Recombinant Mouse Dickkopf-Related Protein 1","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Mouse Dickkopf-Related Protein 1\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eDickkopf-related protein 1 (DKK1) antagonizes canonical Wnt signaling by inhibiting LRP5\/6 interaction with Wnt and by creating a ternary complex with the transmembrane protein KREMEN which promotes internalization of LRP5\/6. DKKs have a significant role in vertebrate development, where they locally inhibit Wnt controlled processes for instance antero-posterior axial patterning, limb development, somitogenesis and eye formation. Furthermore, Dkks are involved in bone formation and bone disease, cancer and Alzheimer disease in Adults.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"2 ug","offer_id":53038183317869,"sku":"pro-2756-2UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10 ug","offer_id":53038544945517,"sku":"pro-2756-10UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038544978285,"sku":"pro-2756-100UG","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-dkk1-mouse-PRO-2756.png?v=1782158394","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-mouse-dickkopf-related-protein-1-bhp11006088","provider":"BioHippo","version":"1.0","type":"link"}