{"product_id":"recombinant-mouse-gdnf-family-receptor-alpha-1-gfra1-bhp10507706","title":"Recombinant Mouse GDNF family receptor alpha-1 (Gfra1)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003eGfra1\u003c\/strong\u003e from Mus musculus (Mouse), produced in Mammalian cell (region 25-430aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 25-430aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e Mammalian cell (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e His (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as GDNF receptor alpha-1 (GDNFR-alpha-1) (GFR-alpha-1) (TGF-beta-related neurotrophic factor receptor 1) (Gdnfra) (Trnr1). Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eQuantitative mapping of ligand\/receptor signaling to downstream phospho- and transcriptional programs.\u003c\/li\u003e\n\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eReceptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving Gfra1\u003c\/li\u003e\n\u003cli\u003eBinding interaction studies (e.g., SPR\/BLI or plate-based binding formats)\u003c\/li\u003e\n\u003cli\u003eCell-based stimulation studies with downstream marker readouts (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB P97785 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P97785 - NCBI Gene search: Gfra1 — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Gfra1 - Ensembl search: Gfra1 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Gfra1 - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053421879661,"sku":"CSB-MP009379MO-1MG","price":2264.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053564289389,"sku":"CSB-MP009379MO-100UG","price":344.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53053564322157,"sku":"CSB-MP009379MO-20UG","price":138.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-MP009379MO-SDS.jpg?v=1772177701","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-mouse-gdnf-family-receptor-alpha-1-gfra1-bhp10507706","provider":"BioHippo","version":"1.0","type":"link"}