{"product_id":"recombinant-mouse-tfr-n-8his-bhp15200081","title":"Recombinant Mouse TfR (N-8His)","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTfR\u003c\/strong\u003e is a target studied in immunology \u0026amp; inflammation research. The sections below provide general scientific background to support interpretation-focused decision making.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene\/target\u003c\/strong\u003e: TfR\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names\u003c\/strong\u003e: Transferrin receptor protein 1, TR, TfR\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAccession\u003c\/strong\u003e: Q62351\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecies context\u003c\/strong\u003e: Mouse\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSequence\/region note:\u003c\/strong\u003e Recombinant constructs are often produced as defined fragments or domains. This product corresponds to an expressed region annotated as \u003cstrong\u003eCys89-Phe763\u003c\/strong\u003e, which may represent a specific portion of the full-length protein used for controlled studies.\u003c\/p\u003e\u003ch2\u003eBiological role and pathway context\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTfR\u003c\/strong\u003e is a receptor-associated target commonly studied for how extracellular cues are translated into intracellular signaling outputs. Receptor behavior can be influenced by ligand availability, co-receptors, clustering, and regulated trafficking, which together shape downstream pathway activity.\u003c\/p\u003e\u003cp\u003eIn \u003cstrong\u003eImmunology \u0026amp; Inflammation\u003c\/strong\u003e research, TfR is often discussed within themes such as immune signaling networks, cytokine and receptor communication, cell trafficking and inflammatory regulation. These themes can help frame interpretation of molecular measurements in relation to broader biological programs.\u003c\/p\u003e\u003cp\u003eReceptor signaling is often embedded in feedback loops and cross-talk with parallel pathways. As a result, changes in receptor abundance or state may reflect altered expression, shedding, or compartmentalization rather than a single causal step.\u003c\/p\u003e\u003cp\u003eRelated molecules considered in interpretation may include cognate ligands, adaptor proteins, kinases\/phosphatases that relay signals, and downstream transcriptional markers that report pathway activation.\u003c\/p\u003e\u003ch2\u003eExpression and regulation\u003c\/h2\u003e\u003cp\u003eExpression of \u003cstrong\u003eTfR\u003c\/strong\u003e can be regulated at multiple levels, including transcriptional control, mRNA stability, translation, and protein turnover. Many targets also exhibit context-dependent expression across tissues or model systems and may respond dynamically to stress, growth cues, immune stimulation, or metabolic state. When comparing datasets, consider species, cell type, stimulus, and time course.\u003c\/p\u003e\u003ch2\u003eIsoforms and molecular forms\u003c\/h2\u003e\u003cp\u003eMany proteins exist as alternative isoforms or processed forms, and post-translational modifications (for example, phosphorylation, glycosylation, acetylation, or proteolytic processing) can alter localization, interactions, or activity. When interpreting results involving \u003cstrong\u003eTfR\u003c\/strong\u003e, consider whether studies distinguish full-length protein from specific domains or fragments, and whether modification states are relevant to the biological question.\u003c\/p\u003e\u003ch2\u003eWhy it matters in research\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePathway interpretation:\u003c\/strong\u003e helps connect molecular changes to network-level hypotheses in immunology \u0026amp; inflammation studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eComparative analysis:\u003c\/strong\u003e supports cross-condition or cross-model comparisons when nomenclature and context are aligned.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystems context:\u003c\/strong\u003e often interpreted alongside related pathway components to distinguish direct effects from secondary changes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eDisease and process relevance\u003c\/h2\u003e\u003cp\u003eDepending on the target, published studies may report associations between \u003cstrong\u003eTfR\u003c\/strong\u003e and disease mechanisms or physiological processes. Such associations are typically context dependent and are best interpreted alongside complementary markers and functional readouts, rather than as standalone evidence.\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50 ug","offer_id":53012019315053,"sku":"EPT081-50UG","price":427.7,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/1hlhkoede157u6613b_b725915c-f373-4023-9538-d826efba338c.jpg?v=1770440686","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-mouse-tfr-n-8his-bhp15200081","provider":"BioHippo","version":"1.0","type":"link"}