{"product_id":"recombinant-pig-interleukin-4-receptor-subunit-alpha-il4r-partial-bhp10507902","title":"Recombinant Pig Interleukin-4 receptor subunit alpha (IL4R), partial","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003eIL4R\u003c\/strong\u003e from Sus scrofa (Pig), produced in Yeast (region 33-240aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 33-240aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e Yeast (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e His (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as CD_antigen: CD124 (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA). Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1\/2\/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4\/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1\/IRS2.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eQuantitative mapping of ligand\/receptor signaling to downstream phospho- and transcriptional programs.\u003c\/li\u003e\n\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eReceptor for both interleukin 4 and interleukin 13. Couples to the JAK1\/2\/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4\/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1\/IRS2.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving IL4R\u003c\/li\u003e\n\u003cli\u003eBinding interaction studies (e.g., SPR\/BLI or plate-based binding formats)\u003c\/li\u003e\n\u003cli\u003eCell-based stimulation studies with downstream marker readouts (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB Q863Z5 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q863Z5 - NCBI Gene search: IL4R — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IL4R - Ensembl search: IL4R — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IL4R - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053427319149,"sku":"CSB-YP771258PI-1MG","price":2959.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053576544621,"sku":"CSB-YP771258PI-100UG","price":694.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53053576577389,"sku":"CSB-YP771258PI-20UG","price":368.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-YP771258PI-SDS.jpg?v=1772177725","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-pig-interleukin-4-receptor-subunit-alpha-il4r-partial-bhp10507902","provider":"BioHippo","version":"1.0","type":"link"}