{"product_id":"recombinant-rat-calbindin-1-bhp11002937","title":"Recombinant Rat Calbindin-1","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Rat Calbindin-1\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eCalbindins are Ca-binding proteins belonging to the troponin C superfamily. CALB28K\/Calbindin1\/CALB1 (D28K\/Spot35 protein or cholecalcin, rat 261 aa; mouse 261 aa; human 261-aa, chromosome 8q21.3-q22.1) was originally described as 27-kDA induced by vitamin D in the duodenum of chicken. In mammals, it is expressed in the kidney, pancreatic islets, and brain. In brain, its synthesis is independent of vitamin D. CABP28K contains 4 active and 2 inactive EF-hand Ca-binding domains. The gene for CABP28K is clustered in the same region as carbonic anhydrase. The neurons in the brains of patients with Huntington disease are CAB28K depleted. There are two types of CaBPs: the \"trigger\"- and the \"buffer\"-CaBPs. The conformation of \"trigger\" type CaBPs changes upon Ca2+ binding and exposes regions on protein that interact with target molecules, thus altering their activity. The buffer-type CABP are thought to control the intracellular calcium concentration. Calbindin D-28K is found predominantly in subpopulations of central and peripheral nervous system neurons, and in certain epithelial cells involved in Ca2+ transport such as distal tubular cells and cortical collecting tubules of the kidney, and in enteric neuroendocrine cells.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"1 ug","offer_id":53038096679277,"sku":"pro-400-1UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53038375797101,"sku":"pro-400-5UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038375829869,"sku":"pro-400-100UG","price":2500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-calb1-rat-PRO-400.png?v=1782158227","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-rat-calbindin-1-bhp11002937","provider":"BioHippo","version":"1.0","type":"link"}