{"product_id":"recombinant-rat-vascular-cell-adhesion-protein-1-vcam1-partial-bhp10507381","title":"Recombinant Rat Vascular cell adhesion protein 1 (Vcam1), partial","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003eVcam1\u003c\/strong\u003e from Rattus norvegicus (Rat), produced in E.coli (region 31-697aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 31-697aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e E.coli (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e His (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as CD106. Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4\/beta-1 (ITGA4\/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1\/ITGA4\/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eImportant in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4\/beta-1 (ITGA4\/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1\/ITGA4\/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte igration to sites of inflammation.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving Vcam1\u003c\/li\u003e\n\u003cli\u003eBinding and specificity benchmarking for detection reagents (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB P29534 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P29534 - NCBI Gene search: Vcam1 — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Vcam1 - Ensembl search: Vcam1 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Vcam1 - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053410771309,"sku":"CSB-EP025809RA1-1MG","price":2466.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053543121261,"sku":"CSB-EP025809RA1-100UG","price":578.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53053543154029,"sku":"CSB-EP025809RA1-20UG","price":306.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-RP167294r-SDS.jpg?v=1772177665","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-rat-vascular-cell-adhesion-protein-1-vcam1-partial-bhp10507381","provider":"BioHippo","version":"1.0","type":"link"}