{"product_id":"recombinant-wheat-gliadin-gamma-18-6kd-bhp11003397","title":"Recombinant Wheat Gliadin Gamma 18.6kD","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Wheat Gliadin Gamma 18.6kD\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eWheat Gliadin and related gluten components from barley, rye and possibly oats can cause an abnormal immune response called Celiac disease which is a chronic gastrointestinal disorder. Celiac disease characteristics are flattening of the jejunal mucosa and intestinal lesions of variable severity in hereditarily inclined individuals. Even though Celiac disease is not a classic autoimmune disease it is related to anti-tissue transglutaminase antibodies and gliadin antibodies tests are most recommended in screening populations at risk for CD and other gluten-sensitive enteropathies. In the past, serologic tests for gliadin antibodies usually were not very precise and were not enough for accurate diagnosis due to missing deamidated epitopes within the authentic gliadin fraction traditionally used in diagnostic test kits. ProSpec's deamidated Gliadin isoform matches to the deamidated neo-epitopes, which in the natural antigen are formed by transglutaminase-mediated glutamine side chain deamidation.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunological functions:\u003c\/strong\u003e 1. Binds IgG- and IgA-type human autoantibodies associated with celiac disease.\u003cbr\u003e2. Standard ELISA test (checkerboard analysis of positive\/negative sera panels); immunodot.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoating concentration:\u003c\/strong\u003e 0.15-0.5 µg\/ml (depending on the type of ELISA plate and coating buffer).\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038110998893,"sku":"pro-114-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038403813741,"sku":"pro-114-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038403846509,"sku":"pro-114-1MG","price":3900.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-gliadin-wheat-PRO-114.png?v=1782158258","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-wheat-gliadin-gamma-18-6kd-bhp11003397","provider":"BioHippo","version":"1.0","type":"link"}