{"product_id":"rem2-antibody-rad-and-gem-like-gtp-binding-protein-2-bha17135406","title":"REM2 Antibody \/ Rad and Gem-like GTP-binding protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eREM2 Antibody \/ Rad and Gem-like GTP-binding protein 2 is a anti-REM2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e REM2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eREM2 antibody detects Ras-related protein REM2, a small GTP-binding protein belonging to the RGK (Rad, Gem, Kir, and Rem) family of Ras-like GTPases. REM2 regulates calcium channel activity, cytoskeletal organization, and neuronal development. Unlike classical Ras proteins, REM2 lacks membrane-targeting motifs and is primarily cytosolic. The REM2 antibody is used in neuroscience and signaling research to study calcium regulation, neuronal differentiation, and small GTPase function.\u003cbr\u003e\u003cbr\u003eREM2 is encoded by the REM2 gene on human chromosome 14q23.2. The protein is approximately 36 kilodaltons and shares structural similarity with other RGK family members. It acts as a potent inhibitor of voltage-dependent calcium channels by binding to beta subunits, reducing calcium influx in excitable cells. This activity modulates neuronal excitability and synaptic plasticity, linking REM2 expression to learning and memory processes.\u003cbr\u003e\u003cbr\u003eThe REM2 antibody detects a 36-38 kilodalton protein by western blot and exhibits cytoplasmic staining in neurons, muscle cells, and other excitable tissues. REM2 expression is dynamically regulated by neuronal activity and signaling pathways involving calcium\/calmodulin-dependent kinases and cAMP response element-binding protein (CREB). Overexpression of REM2 suppresses calcium current density, alters actin filament organization, and inhibits dendritic spine formation. Conversely, its downregulation promotes neurite outgrowth and synaptic connectivity.\u003cbr\u003e\u003cbr\u003eBeyond neuronal contexts, REM2 contributes to cytoskeletal remodeling and cell proliferation. It interacts with 14-3-3 proteins and signaling kinases, coordinating calcium-dependent gene expression and structural plasticity. Dysregulation of REM2 has been associated with mood disorders, neuropathic pain, and cardiac remodeling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=REM2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=REM2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=REM2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/REM2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=REM2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047290364269,"sku":"FY12503","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4418c968-d4ab-4211-9c31-921401c64924.jpg?v=1782237014","url":"https:\/\/www.ebiohippo.com\/products\/rem2-antibody-rad-and-gem-like-gtp-binding-protein-2-bha17135406","provider":"BioHippo","version":"1.0","type":"link"}