{"product_id":"rere-antibody-arginine-glutamic-acid-dipeptide-repeats-protein-bha17136222","title":"RERE Antibody \/ Arginine-glutamic acid dipeptide repeats protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRERE Antibody \/ Arginine-glutamic acid dipeptide repeats protein is a anti-RERE Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RERE\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRERE antibody detects Arginine-glutamic acid dipeptide repeats protein, a predominantly nuclear transcriptional coregulator encoded by the RERE gene on chromosome 1p36.23. RERE belongs to the atrophin protein family and functions as a transcriptional regulator that influences embryonic development, cell differentiation, and apoptosis. The protein localizes mainly to the nucleus but can also be found in the cytoplasm depending on signaling state. RERE acts as a transcriptional coregulator that modulates gene expression by interacting with nuclear receptors and chromatin-modifying enzymes, integrating developmental signals and apoptotic pathways.\u003cbr\u003e\u003cbr\u003eRERE serves as both a coactivator and corepressor for nuclear receptors such as retinoic acid receptor (RAR) and histone deacetylases (HDACs), linking transcriptional regulation with epigenetic modification. It plays an essential role in retinoic acid signaling, a pathway required for proper embryonic tissue differentiation. Through its interactions with transcription factors and epigenetic complexes, RERE controls gene expression patterns that direct neuronal patterning, heart formation, and eye morphogenesis. Its chromatin-association properties make it a central player in gene regulatory networks that define developmental outcomes.\u003cbr\u003e\u003cbr\u003eMutations or deletions in the RERE gene are associated with 1p36 deletion syndrome and RERE-related neurodevelopmental disorders, which cause developmental delay, hypotonia, and congenital malformations. Functional studies in model organisms show that loss of RERE disrupts neural crest migration, cardiac outflow tract formation, and craniofacial development. The protein's regulatory activity within retinoic acid signaling links it to both morphogenetic and metabolic control during embryogenesis.\u003cbr\u003e\u003cbr\u003eAt the molecular level, RERE interacts with HDAC1\/2, p300\/CBP, and other transcriptional repressors to modulate chromatin accessibility. These interactions determine whether RERE acts as a transcriptional activator or repressor depending on context. RERE also influences p53-dependent apoptosis and tumor suppression, highlighting its dual role in development and cancer. Reduced RERE expression has been observed in certain malignancies, suggesting a protective function against tumorigenesis.\u003cbr\u003e\u003cbr\u003eStructurally, RERE contains an N-terminal Atrophin-1 domain, several arginine\/glutamic acid-rich repeats, and nuclear localization signals that facilitate chromatin binding. Its modular architecture allows multiple protein interactions, and its Atrophin-like region contributes to transcriptional repression. Evolutionarily, RERE is conserved among vertebrates and classified within the atrophin family of transcriptional regulators, known for controlling gene silencing and differentiation. RERE is also implicated in pathways such as retinoic acid signaling and chromatin remodeling, reflecting its multifunctional nature.\u003cbr\u003e\u003cbr\u003eImmunohistochemical staining using RERE antibody demonstrates nuclear localization in neurons, cardiac myocytes, and developing epithelia. The RERE antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RERE - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RERE - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RERE - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RERE - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RERE+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047322149229,"sku":"FY13320","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c002295c-7dc7-4392-a94a-3f24c593c937.jpg?v=1782237112","url":"https:\/\/www.ebiohippo.com\/products\/rere-antibody-arginine-glutamic-acid-dipeptide-repeats-protein-bha17136222","provider":"BioHippo","version":"1.0","type":"link"}