{"product_id":"resiniferatoxin-bhb21300314","title":"Resiniferatoxin","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)- 3a,3b,6,6a,9a,10,11,11aoctahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9 b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneaceta.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Reciniferatoxin, RTX\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 57444-62-9\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C37H40O9.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e 95-98% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 20 nM - 1 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRPV1 channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Natural\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Resiniferatoxin is a potent and selective activator of the TRPV1 (Vanilloid\/Capsaicin receptor 1) channel1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e Reciniferatoxin, RTX\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eResiniferatoxin is a potent and selective agonist of the TRPV1 (Vanilloid\/Capsaicin receptor) channel.1 Application of sub-nanomolar concentrations of Resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons.2Treatment of rats with Resiniferatoxin, like treatment with capsaicin, causes hypothermia, neurogenic inflammation and pain. These responses were followed by a loss of thermoregulation, by desensitization to neurogenic inflammation and by chemical and thermal analgesia, with a cross-tolerance between Resiniferatoxin and capsaicin.1\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e \u003ch3\u003eCited application(s)\u003c\/h3\u003e \u003cp\u003eElectrophysiology\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"0.5 mg \/ 1","offer_id":53249713865069,"sku":"R-400-0P5MG-1","price":1728.0,"currency_code":"USD","in_stock":true},{"title":"50 mcg \/ 1","offer_id":53311575785837,"sku":"R-400-50MCG-1","price":358.0,"currency_code":"USD","in_stock":true},{"title":"0.5 mg \/ 5","offer_id":53311575818605,"sku":"R-400-0P5MG-5","price":6910.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/R-400-Resiniferatoxin-100nM-on-TRPV1-in-oocytes.jpg?v=1778544450","url":"https:\/\/www.ebiohippo.com\/products\/resiniferatoxin-bhb21300314","provider":"BioHippo","version":"1.0","type":"link"}