{"product_id":"retinoschisin-antibody-rs1-bha17135331","title":"Retinoschisin Antibody \/ RS1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRetinoschisin Antibody \/ RS1 is a anti-RS1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RS1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe Retinoschisin antibody targets Retinoschisin, a secreted cell-adhesion protein encoded by the RS1 gene and essential for maintaining the structural integrity of the retina. Retinoschisin is produced primarily by photoreceptor and bipolar cells and forms a disulfide-linked octamer that mediates cell-cell adhesion and retinal layer organization. The Retinoschisin antibody provides a crucial tool for studying retinal development, synaptic architecture, and inherited retinal disorders such as X-linked juvenile retinoschisis (XLRS).\u003cbr\u003e\u003cbr\u003eRetinoschisin localizes to the inner surface of photoreceptor and bipolar cell membranes, where it contributes to the formation of organized laminar structures necessary for signal transmission. The Retinoschisin antibody supports visualization of its localization within the outer and inner plexiform layers, providing insights into cell adhesion and extracellular matrix interactions. Through binding to membrane lipids and extracellular partners such as Na\/K ATPase and L-type calcium channels, Retinoschisin stabilizes synaptic connectivity and retinal tissue architecture.\u003cbr\u003e\u003cbr\u003eMutations in the RS1 gene result in XLRS, a heritable vitreoretinal dystrophy characterized by splitting of the retinal layers and loss of central vision. The Retinoschisin antibody facilitates research into this condition by detecting the presence or absence of Retinoschisin in patient samples and model systems. Defective or truncated protein forms lead to impaired secretion and defective cell adhesion, causing structural disorganization of the retina and progressive visual impairment.\u003cbr\u003e\u003cbr\u003eBeyond its structural role, Retinoschisin influences retinal signaling pathways that regulate photoreceptor synapse function. The Retinoschisin antibody allows for quantitative studies assessing protein levels under different light-adaptation states or disease conditions. In addition, Retinoschisin is being explored as a candidate for gene-replacement therapy, and antibody-based detection is vital for evaluating therapeutic expression and localization.\u003cbr\u003e\u003cbr\u003eThe Retinoschisin antibody performs effectively in western blotting, immunohistochemistry, and immunofluorescence, yielding punctate staining in retinal layers consistent with extracellular distribution.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RS1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RS1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RS1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RS1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RS1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047289151853,"sku":"FY12428","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_cadd66b8-674c-4c52-81ae-fab33dd614de.jpg?v=1782237003","url":"https:\/\/www.ebiohippo.com\/products\/retinoschisin-antibody-rs1-bha17135331","provider":"BioHippo","version":"1.0","type":"link"}