{"product_id":"rh-35-cell-bhc11101185","title":"RH-35 cell","description":"The H4-II-E (also referred to as RH-35) cell line is a derivative of the Reuber H-35 rat hepatoma. This cell line originated from a liver tumor induced in a male ACI rat by exposure to the chemical carcinogen N-2-fluorenyldiacetamide. When transplanted into ACI rats, H4-II-E cells form rapidly growing tumors with histological features characteristic of poorly differentiated hepatomas. They are particularly sensitive to the induction of aryl hydrocarbon hydroxylase (AHH) activity, making them a robust system for studying enzymatic responses to polycyclic aromatic hydrocarbons and dioxin-like compounds.\n\nH4-II-E cells also serve as a model for studying cellular responses to carcinogens and radiation, given their clonogenicity and the ability to assay long-term cell survival post-treatment. Their application extends to exploring the mechanisms of enzyme induction, xenobiotic metabolism, and liver-specific toxicology. These attributes make H4-II-E an invaluable tool in cancer research and toxicological screening.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101185\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950222766445,"sku":"305210","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/RH-35-_281_29_1920x1920_db83c1b2-8396-4885-b62f-e91d1f4b18ac.jpg?v=1769069207","url":"https:\/\/www.ebiohippo.com\/products\/rh-35-cell-bhc11101185","provider":"BioHippo","version":"1.0","type":"link"}