{"product_id":"ripk2-antibody-receptor-interacting-serine-threonine-kinase-2-bha17135954","title":"RIPK2 Antibody \/ Receptor interacting serine threonine kinase 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRIPK2 Antibody \/ Receptor interacting serine threonine kinase 2 is a anti-RIPK2 Rabbit antibody Recombinant Rabbit Monoclonal clone 31R02 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RIPK2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31R02, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRIPK2 antibody detects Receptor interacting serine threonine kinase 2, encoded by the RIPK2 gene. This cytoplasmic kinase belongs to the RIP kinase family and is a critical mediator of innate immune signaling downstream of nucleotide binding oligomerization domain (NOD) receptors. By integrating microbial sensing with downstream NF kappa B and MAP kinase activation, RIPK2 helps coordinate proinflammatory gene expression. RIPK2 antibody provides a valuable reagent for studying innate immunity, inflammation, and host pathogen interactions.\u003cbr\u003e\u003cbr\u003eReceptor interacting serine threonine kinase 2 is activated by NOD1 and NOD2, intracellular pattern recognition receptors that detect bacterial peptidoglycan. Upon ligand recognition, NOD proteins recruit RIPK2 through caspase activation and recruitment domains, leading to kinase activation and signaling complex formation. Research using RIPK2 antibody has shown that this kinase is indispensable for NF kappa B activation, cytokine production, and antimicrobial defense. By functioning as a central signaling hub, RIPK2 links bacterial detection to adaptive immune responses.\u003cbr\u003e\u003cbr\u003eBeyond antimicrobial defense, RIPK2 contributes to autophagy and regulation of cell death. Studies with RIPK2 antibody have demonstrated that it interacts with autophagy proteins to clear intracellular bacteria. Dysregulation of RIPK2 signaling can lead to pathological inflammation, contributing to Crohn disease, Blau syndrome, and other autoinflammatory conditions. Mutations in RIPK2 or its upstream activators alter immune responses and are associated with susceptibility to chronic inflammatory disease.\u003cbr\u003e\u003cbr\u003eIn oncology, aberrant RIPK2 activation has been linked to tumor progression and immune evasion. Research with RIPK2 antibody has revealed that overexpression or hyperactivation of this kinase promotes survival pathways in cancer cells and contributes to a proinflammatory tumor microenvironment. Inhibition of RIPK2 is being investigated as a therapeutic strategy to reduce chronic inflammation and enhance cancer immunotherapy outcomes.\u003cbr\u003e\u003cbr\u003eRIPK2 antibody is widely used in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting demonstrates phosphorylation dependent activation, immunohistochemistry highlights expression in inflamed tissues, and immunoprecipitation isolates complexes formed during NOD signaling. These applications make RIPK2 antibody a versatile reagent for both basic and translational immunology.\u003cbr\u003e\u003cbr\u003eBy supplying validated RIPK2 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RIPK2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RIPK2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RIPK2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RIPK2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RIPK2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047310549357,"sku":"FY13052","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5658d095-7117-4392-b3bc-794d84b047d7.jpg?v=1772019384","url":"https:\/\/www.ebiohippo.com\/products\/ripk2-antibody-receptor-interacting-serine-threonine-kinase-2-bha17135954","provider":"BioHippo","version":"1.0","type":"link"}