{"product_id":"rpl24-antibody-60s-ribosomal-protein-l24-bha17135807","title":"RPL24 Antibody \/ 60S ribosomal protein L24","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRPL24 Antibody \/ 60S ribosomal protein L24 is a anti-RPL24 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RPL24\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRPL24 antibody detects 60S ribosomal protein L24, a structural component of the large ribosomal subunit essential for protein synthesis. Encoded by the RPL24 gene on chromosome 3p21.3, this ribosomal protein contributes to ribosome assembly, rRNA processing, and translation elongation. RPL24 participates in maintaining translational fidelity and efficiency, influencing cell growth, proliferation, and metabolic control.\u003cbr\u003e\u003cbr\u003eStructurally, RPL24 is a 157-amino-acid protein of approximately 18 kilodaltons that forms part of the ribosomal 60S subunit. It is highly conserved across species and interacts with ribosomal RNA and neighboring proteins to stabilize the ribosomal architecture. RPL24 localizes predominantly to the cytoplasm and nucleolus, reflecting its dual role in ribosome biogenesis and cytoplasmic translation.\u003cbr\u003e\u003cbr\u003eThe RPL24 antibody is widely used in molecular biology, cancer research, and translational control studies to analyze ribosome composition, protein synthesis rates, and growth regulation. Western blot analysis identifies an 18 kilodalton band corresponding to RPL24, while immunofluorescence shows strong cytoplasmic and nucleolar localization. This antibody supports research examining how ribosomal proteins coordinate mRNA translation with cellular metabolism and proliferation.\u003cbr\u003e\u003cbr\u003eFunctionally, RPL24 promotes ribosome maturation by assisting in 28S rRNA folding and subunit joining. Reduced RPL24 expression impairs translation efficiency and causes growth defects, while overexpression supports rapid proliferation in tumor cells. Mutations in ribosomal proteins including RPL24 are associated with developmental syndromes and cancers characterized by deregulated protein synthesis. The RPL24 antibody provides a critical tool for studying ribosome biogenesis, translational regulation, and ribosomal stress responses.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RPL24 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RPL24 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RPL24 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RPL24 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RPL24+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047305732461,"sku":"FY12905","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_56df79b6-419b-47be-9534-4a71fe6f6893.jpg?v=1782237056","url":"https:\/\/www.ebiohippo.com\/products\/rpl24-antibody-60s-ribosomal-protein-l24-bha17135807","provider":"BioHippo","version":"1.0","type":"link"}