{"product_id":"rprd1b-antibody-bha10807448","title":"RPRD1B antibody","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003ePrimary Antibody\u003c\/span\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eRPRD1B antibody\u003c\/strong\u003e is a polyclonal primary antibody raised in Rabbit against RPRD1B. The antibody is documented by Fine Test for use in ELISA, Western Blot.\u003c\/p\u003e\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eInteracts with phosphorylated C-terminal heptapeptide repeat domain(CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.\u003c\/p\u003e\n\u003ch2\u003eValidated Applications \u0026amp; Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eValidated Applications\u003c\/th\u003e\n\u003ctd\u003eELISA, Western Blot\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eRecommended Dilution\u003c\/th\u003e\n\u003ctd\u003eWB: 1:500-1:2000\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eHost Species\u003c\/th\u003e\n\u003ctd\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003ePredicted Molecular Weight\u003c\/th\u003e\n\u003ctd\u003e37 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e≥95% as determined by SDS-PAGE\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003ePurification\u003c\/th\u003e\n\u003ctd\u003eImmunogen Affinity Purified\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eFormulation \/ Buffer\u003c\/th\u003e\n\u003ctd\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eUniProt \/ Accession\u003c\/th\u003e\n\u003ctd\u003eQ9NQG5\u003c\/td\u003e\n\u003c\/tr\u003e\n\n    \u003ctr\u003e\n\u003cth\u003eGene ID\u003c\/th\u003e\n\u003ctd\u003e58490\u003c\/td\u003e\n\u003c\/tr\u003e\n\n\u003c\/table\u003e\n\u003ch2\u003eImmunogen \/ Antigen\u003c\/h2\u003e\n\u003cp\u003eregulation of nuclear pre-mRNA domain containing 1B\u003c\/p\u003e\n\u003ch2\u003eReactivity Notes\u003c\/h2\u003e\n\u003cp\u003eDocumented species reactivity: Human.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"bhp-qc-badge\"\u003eQuality control: ≥95% as determined by SDS-PAGE\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003eThis product is intended \u003cstrong\u003efor research use only (RUO)\u003c\/strong\u003e. It is not intended for use in diagnostic or therapeutic procedures.\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze \/ thaw cycles.)\u003c\/p\u003e\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eBrowse additional primary antibodies and immunodetection reagents from Fine Test available through Biohippo.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Fine Test","offers":[{"title":"100 ug","offer_id":53362397610349,"sku":"FNab07456-100UG","price":364.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/antibody_928de395-b1ea-4cba-a24e-33977d9d6729.jpg?v=1779482509","url":"https:\/\/www.ebiohippo.com\/products\/rprd1b-antibody-bha10807448","provider":"BioHippo","version":"1.0","type":"link"}