{"product_id":"rps19bp1-antibody-ribosomal-protein-s19-binding-protein-1-bha17135630","title":"RPS19BP1 Antibody \/ Ribosomal protein S19-binding protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRPS19BP1 Antibody \/ Ribosomal protein S19-binding protein 1 is a anti-RPS19BP1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human. Reported localization: Nucleus, Nucleolus.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RPS19BP1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRPS19BP1 antibody detects Ribosomal protein S19-binding protein 1 (also known as RPS19BP1 or CGI-96), a conserved nucleolar protein implicated in ribosome biogenesis, RNA processing, and cell proliferation. Encoded by the RPS19BP1 gene on chromosome 22q13.2, this protein binds ribosomal protein S19 and possibly other ribosomal components, assisting in pre-rRNA maturation and ribosome assembly. RPS19BP1 contains coiled-coil and low-complexity regions that may mediate protein-protein interactions within the nucleolus. Although initially identified as a ribosome-associated factor, emerging evidence suggests roles in DNA repair and RNA metabolism.\u003cbr\u003e\u003cbr\u003eRPS19BP1 is predominantly localized to the nucleolus and nucleoplasm, where it contributes to the assembly of ribosomal subunits and maintenance of rRNA transcription. Depletion of RPS19BP1 results in reduced 40S ribosomal subunit formation and impaired protein synthesis. Given the central role of ribosome biogenesis in cell growth, dysregulation of RPS19BP1 affects proliferation and stress response pathways. The protein has been linked to hematopoietic development, as mutations or altered expression may influence erythropoiesis through its association with RPS19, a protein mutated in Diamond-Blackfan anemia.\u003cbr\u003e\u003cbr\u003eThe RPS19BP1 antibody is used in molecular biology and hematology research to study nucleolar function, ribosomal assembly, and cell growth control. Western blot analysis identifies a 58 kilodalton band corresponding to RPS19BP1, while immunofluorescence demonstrates strong nucleolar staining patterns. In proliferating cells, RPS19BP1 colocalizes with fibrillarin and other rRNA processing factors. Because nucleolar integrity is sensitive to stress, this antibody is also applied in experiments assessing nucleolar stress and its effects on p53 stabilization.\u003cbr\u003e\u003cbr\u003eBeyond ribosome biogenesis, RPS19BP1 may have additional regulatory roles in chromatin remodeling and transcriptional control. Its interaction network includes several chromatin-binding and RNA-processing proteins. Aberrant expression of RPS19BP1 has been noted in certain cancers, linking ribosomal stress to tumorigenesis. The RPS19BP1 antibody therefore provides an essential tool for investigating nucleolar function, ribosomal disorders, and the interface between protein synthesis and cell cycle control.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RPS19BP1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RPS19BP1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RPS19BP1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RPS19BP1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RPS19BP1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047298195821,"sku":"FY12727","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_db0ab076-b7e8-478d-ba92-feeb13c7fd64.jpg?v=1782237034","url":"https:\/\/www.ebiohippo.com\/products\/rps19bp1-antibody-ribosomal-protein-s19-binding-protein-1-bha17135630","provider":"BioHippo","version":"1.0","type":"link"}