{"product_id":"rsl24d1-antibody-ribosomal-l24-domain-containing-protein-1-bha17136152","title":"RSL24D1 Antibody \/ Ribosomal L24 domain-containing protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRSL24D1 Antibody \/ Ribosomal L24 domain-containing protein 1 is a anti-RSL24D1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nucleolus.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RSL24D1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRSL24D1 antibody detects Ribosomal L24 domain-containing protein 1, a nucleolar factor involved in ribosome biogenesis and pre-rRNA processing. The UniProt recommended name is Ribosomal L24 domain-containing protein 1 (RSL24D1). This protein plays a key role in the maturation of the large 60S ribosomal subunit and the assembly of functional ribosomes necessary for protein synthesis and cell growth.\u003cbr\u003e\u003cbr\u003eFunctionally, RSL24D1 antibody identifies a 332-amino-acid nucleolar protein that associates with preribosomal complexes during 60S subunit assembly. RSL24D1 interacts with rRNA intermediates and ribosomal proteins to facilitate cleavage and folding events required for ribosome maturation. It participates in the late steps of rRNA processing, ensuring proper incorporation of 28S rRNA into the large subunit. RSL24D1 is functionally conserved across eukaryotes, underscoring its central role in ribosome biogenesis.\u003cbr\u003e\u003cbr\u003eThe RSL24D1 gene is located on chromosome 15q25.2 and is expressed in proliferative tissues such as bone marrow, testis, and liver, where active ribosome production supports rapid cell growth. Expression levels correlate with translational demand and are tightly controlled by growth factor and nutrient signaling pathways that regulate ribosome assembly.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of RSL24D1 affects ribosomal homeostasis and has been linked to cancer and ribosomopathies. Overexpression promotes cell proliferation and is associated with tumor growth, while loss of function leads to impaired ribosome production and nucleolar stress. RSL24D1 interacts with tumor suppressor pathways, including p53 activation in response to ribosomal imbalance. Research using RSL24D1 antibody supports studies in translation regulation, cancer biology, and ribosome assembly mechanisms.\u003cbr\u003e\u003cbr\u003eRSL24D1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect nucleolar ribosome assembly proteins. \u003cbr\u003e\u003cbr\u003eStructurally, Ribosomal L24 domain-containing protein 1 contains a conserved L24-like domain characteristic of large ribosomal subunit proteins, facilitating interactions with rRNA and assembly factors. Its C-terminal region mediates nucleolar localization and binding to preribosomal complexes. This antibody enables detailed investigation of RSL24D1's role in ribosome biogenesis, translational control, and cellular growth regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RSL24D1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RSL24D1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RSL24D1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RSL24D1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RSL24D1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047320052077,"sku":"FY13250","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f2adf263-2d5a-44c4-bb71-99d55763fe73.jpg?v=1782237091","url":"https:\/\/www.ebiohippo.com\/products\/rsl24d1-antibody-ribosomal-l24-domain-containing-protein-1-bha17136152","provider":"BioHippo","version":"1.0","type":"link"}