{"product_id":"rsrc2-antibody-arginine-serine-rich-coiled-coil-protein-2-bha17136016","title":"RSRC2 Antibody \/ Arginine\/serine-rich coiled-coil protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eRSRC2 Antibody \/ Arginine\/serine-rich coiled-coil protein 2 is a anti-RSRC2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA with listed reactivity in Human. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e RSRC2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eRSRC2 antibody detects Arginine\/serine-rich coiled-coil protein 2, a nuclear splicing factor that regulates pre-mRNA processing and alternative splicing. The UniProt recommended name is Arginine\/serine-rich coiled-coil protein 2 (RSRC2). This serine\/arginine-rich (SR) protein family member modulates spliceosome assembly and mRNA maturation, influencing gene expression across multiple tissues.\u003cbr\u003e\u003cbr\u003eFunctionally, RSRC2 antibody identifies a 477-amino-acid protein localized to nuclear speckles where it associates with splicing machinery components. RSRC2 facilitates exon recognition and splice site selection through interactions with U2AF and SR proteins, ensuring accurate pre-mRNA splicing. It also acts as a transcriptional co-regulator linking splicing to gene expression control.\u003cbr\u003e\u003cbr\u003eThe RSRC2 gene is located on chromosome 12q24.31 and is widely expressed, with enrichment in brain, heart, and testis. RSRC2 activity supports tissue-specific splicing patterns essential for cellular differentiation and development. It dynamically redistributes within the nucleus in response to transcriptional and stress signals, reflecting its role in gene expression regulation.\u003cbr\u003e\u003cbr\u003ePathologically, RSRC2 dysregulation has been implicated in neurodegenerative disease, cancer, and cardiovascular disorders. Altered RSRC2 expression disrupts mRNA splicing fidelity and may affect tumor suppressor or oncogene expression. Research using RSRC2 antibody aids in studies of RNA processing, splicing regulation, and gene expression control.\u003cbr\u003e\u003cbr\u003eRSRC2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect splicing regulators and nuclear speckle proteins. \u003cbr\u003e\u003cbr\u003eStructurally, Arginine\/serine-rich coiled-coil protein 2 contains SR repeats mediating protein interactions and a coiled-coil region that promotes nuclear localization and complex formation. This antibody enables detailed analysis of RSRC2's role in co-transcriptional mRNA processing and cellular homeostasis.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=RSRC2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RSRC2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=RSRC2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/RSRC2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RSRC2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047312351597,"sku":"FY13114","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5da3a466-4f90-4607-b661-3cd27f5013b7.jpg?v=1772019398","url":"https:\/\/www.ebiohippo.com\/products\/rsrc2-antibody-arginine-serine-rich-coiled-coil-protein-2-bha17136016","provider":"BioHippo","version":"1.0","type":"link"}