{"product_id":"s100p-antibody-protein-s100-p-bha17135607","title":"S100P Antibody \/ Protein S100-P","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eS100P Antibody \/ Protein S100-P is a anti-S100P Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS) with listed reactivity in Human. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e S100P\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eS100P antibody detects Protein S100-P (also known as S100 calcium-binding protein P), a member of the S100 family of calcium-binding proteins that regulate diverse cellular processes including cell growth, differentiation, cytoskeletal dynamics, and signal transduction. Encoded by the S100P gene on chromosome 4p16, this small acidic protein contains two EF-hand calcium-binding motifs that undergo conformational change upon calcium binding, enabling interaction with target proteins. Through these calcium-dependent interactions, S100P influences intracellular signaling cascades and modulates cytoskeletal organization, motility, and transcriptional activity.\u003cbr\u003e\u003cbr\u003eS100P is expressed in multiple tissues, including placenta, pancreas, lung, and prostate, and is frequently upregulated in cancers where it contributes to tumor progression and metastasis. The protein interacts with the receptor for advanced glycation end products (RAGE) at the cell surface, activating downstream MAPK and NF-kB pathways that promote proliferation, migration, and resistance to apoptosis. Elevated S100P expression has been associated with poor prognosis in breast, pancreatic, and colorectal carcinomas, making it a biomarker for aggressive tumor phenotypes and potential therapeutic target.\u003cbr\u003e\u003cbr\u003eThe S100P antibody is widely used in cancer biology and molecular pathology to study calcium signaling and metastasis regulation. In western blot analysis, S100P appears as an approximately 11 kilodalton band corresponding to the monomeric form, while immunohistochemistry reveals both cytoplasmic and nuclear localization depending on cell type. In cancer diagnostics, S100P immunoreactivity is employed to distinguish pancreatic ductal adenocarcinoma from benign pancreatic lesions and to evaluate metastatic spread. The antibody is also valuable in studies of placental function and epithelial differentiation where S100P participates in hormone-responsive signaling networks.\u003cbr\u003e\u003cbr\u003eBeyond oncology, S100P contributes to inflammation and tissue repair. It enhances fibroblast motility and collagen remodeling through calcium-dependent activation of small GTPases such as Rac1 and Cdc42. It also regulates gene transcription by interacting with nuclear receptors and coactivators, influencing expression of stress-response and survival genes. The S100P antibody enables detailed characterization of these pathways, providing insight into the molecular mechanisms that couple calcium signaling to cell behavior. Researchers employ it in western blotting, immunofluorescence, and immunohistochemistry to quantify expression and localization in tissue or cultured cells.\u003cbr\u003e\u003cbr\u003eBecause of its strong link to metastasis, S100P has emerged as a therapeutic target and diagnostic biomarker. Inhibitors of the S100P-RAGE interaction are under investigation for their potential to reduce tumor invasion and inflammation. The S100P antibody supplied by\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=S100P - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=S100P - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=S100P - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/S100P - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=S100P+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047296262509,"sku":"FY12704","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2b499f46-6032-4f1f-be39-6746111459d9.jpg?v=1782237028","url":"https:\/\/www.ebiohippo.com\/products\/s100p-antibody-protein-s100-p-bha17135607","provider":"BioHippo","version":"1.0","type":"link"}