{"product_id":"sb-203580-bhb21300334","title":"SB 203580","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]- 1H-imidazol-4-yl]pyridine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 152121-47-6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C21H16FN3OS.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10-100 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MAPK Homologue-p38\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e SB 203580 is a specific inhibitor for the p38 MAP kinase homologues1-6.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eSB203580 is highly selective and cell permeable pyridinyl imidazole that inhibits the activity of MAP kinase homologs - p38 (stress-activated protein kinase II\/HOG1) and p54 (stress-activated protein kinase I\/c-Jun N-terminal kinase) with IC50 values of 50 and 500 nM for p38\/SAPK2a and p38\/SAPK2b respectively.1-6 SB203580 also inhibits the phosphorylation and activation of protein kinase B (PKB, also known as Akt) by inhibiting the PKB kinase, phosphoinositide-dependent protein kinase 1 (IC50 3-5 µM).7-9\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"1 mg \/ 1","offer_id":53249713930605,"sku":"S-370-1MG-1","price":129.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311577719149,"sku":"S-370-5MG-1","price":223.0,"currency_code":"USD","in_stock":true},{"title":"1 mg \/ 5","offer_id":53311577751917,"sku":"S-370-1MG-5","price":506.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/S-370.gif?v=1778544452","url":"https:\/\/www.ebiohippo.com\/products\/sb-203580-bhb21300334","provider":"BioHippo","version":"1.0","type":"link"}