{"product_id":"sb203580-bhb11900258","title":"SB203580","description":"\u003cp\u003eSB203580 is a pyridinyl imidazole compound that selectively inhibits p38 MAP kinase, particularly the p38α isoform. It also inhibits phosphorylation of heat shock protein 27 (HSP27) and can activate Raf-1 signaling. In neuroscience, SB203580 is used to study the role of p38 MAPK in neuroinflammation, synaptic plasticity, and neuronal survival. Its high selectivity over kinases such as LCK, GSK-3β, and PKBα makes it a reliable tool for dissecting p38-mediated signaling in neurodegenerative disease models. SB203580 is cell-permeable and is frequently employed in studies of Alzheimer's disease, stroke, and other CNS disorders involving inflammatory and stress responses.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040949625197,"sku":"SIH-474-5MG","price":201.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040970039661,"sku":"SIH-474-25MG","price":773.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-474_SB_203580_Chemical_Structure.png?v=1771837651","url":"https:\/\/www.ebiohippo.com\/products\/sb203580-bhb11900258","provider":"BioHippo","version":"1.0","type":"link"}