{"product_id":"sbk1-antibody-sh3-domain-binding-kinase-1-bha17136125","title":"SBK1 Antibody \/ SH3 domain-binding kinase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSBK1 Antibody \/ SH3 domain-binding kinase 1 is a anti-SBK1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SBK1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IP, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSBK1 antibody detects SH3 domain-binding kinase 1, a serine\/threonine protein kinase implicated in neuronal signaling, stress response, and intracellular communication. The UniProt recommended name is SH3 domain-binding kinase 1 (SBK1). This protein belongs to the protein kinase-like (PKL) family and may act as a regulator of ion channel function, cytoskeletal organization, and synaptic plasticity.\u003cbr\u003e\u003cbr\u003eFunctionally, SBK1 antibody identifies a 364-amino-acid cytoplasmic and membrane-associated kinase that contains an N-terminal kinase domain and an SH3-binding motif. SBK1 is expressed primarily in the brain, where it interacts with SH3 domain-containing proteins involved in signal transduction and vesicular trafficking. Although its substrates remain incompletely characterized, SBK1 likely modulates signaling pathways linked to neuronal differentiation and synaptic strength.\u003cbr\u003e\u003cbr\u003eThe SBK1 gene is located on chromosome 16q12.1 and is expressed in brain, skeletal muscle, and heart. Expression levels are regulated by neuronal activity and stress stimuli, suggesting involvement in activity-dependent signaling cascades. SBK1 may function as part of kinase networks that fine-tune cellular responses to excitatory signals and metabolic stress.\u003cbr\u003e\u003cbr\u003ePathologically, altered SBK1 expression has been observed in neurological disorders and cancers. Increased expression has been associated with gliomas and neural tissue remodeling, while reduced expression may impair neuronal communication or contribute to neurodegenerative processes. Research using SBK1 antibody supports studies in neuroscience, kinase signaling, and stress adaptation pathways.\u003cbr\u003e\u003cbr\u003eSBK1 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect neuronal kinases. \u003cbr\u003e\u003cbr\u003eStructurally, SH3 domain-binding kinase 1 contains a conserved catalytic domain with ATP-binding and substrate recognition motifs characteristic of serine\/threonine kinases. Its SH3-binding region facilitates association with signaling scaffolds and adaptor proteins. This antibody enables exploration of SBK1�s role in neuronal signaling, cytoskeletal regulation, and adaptive stress responses.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SBK1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SBK1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SBK1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SBK1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SBK1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047320740205,"sku":"FY13223","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2e6981f1-e145-49b8-8228-7c5dd57960e3.jpg?v=1782237097","url":"https:\/\/www.ebiohippo.com\/products\/sbk1-antibody-sh3-domain-binding-kinase-1-bha17136125","provider":"BioHippo","version":"1.0","type":"link"}