{"product_id":"sc-514-bhb11900259","title":"SC 514","description":"\u003cp\u003eSC 514 is a selective and reversible inhibitor of IκB kinase 2 (IKKβ), a key regulator of the NF-κB signaling pathway. By blocking IKKβ activity, SC 514 prevents the phosphorylation and degradation of IκBα, thereby inhibiting NF-κB activation. In neurodegenerative disease research, SC 514 is used to explore the role of NF-κB in neuroinflammation, glial activation, and neuronal survival. Its \u0026gt;10-fold selectivity over other kinases such as JNK, p38, MK2, and ERK enhances its utility in dissecting inflammatory signaling in the brain. SC 514 is cell-permeable and is a valuable compound for studying therapeutic strategies targeting chronic inflammation in neurodegenerative disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040949821805,"sku":"SIH-475-10MG","price":87.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040969908589,"sku":"SIH-475-50MG","price":338.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-475_SC-514_Chemical_Structure.png?v=1771837648","url":"https:\/\/www.ebiohippo.com\/products\/sc-514-bhb11900259","provider":"BioHippo","version":"1.0","type":"link"}