{"product_id":"scara5-antibody-scavenger-receptor-class-a-member-5-bha17136011","title":"SCARA5 Antibody \/ Scavenger receptor class A member 5","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSCARA5 Antibody \/ Scavenger receptor class A member 5 is a anti-SCARA5 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SCARA5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSCARA5 antibody detects Scavenger receptor class A member 5, a pattern recognition receptor that mediates endocytosis of modified lipoproteins and iron-bound ligands. The UniProt recommended name is Scavenger receptor class A member 5 (SCARA5). This type II transmembrane protein participates in host defense, cellular adhesion, and iron metabolism.\u003cbr\u003e\u003cbr\u003eFunctionally, SCARA5 antibody identifies a 495-amino-acid receptor consisting of a collagen-like domain, a coiled-coil stalk, and a C-terminal scavenger receptor cysteine-rich domain that binds various ligands. SCARA5 acts as a ferritin receptor, mediating non-transferrin-dependent iron uptake. It also recognizes bacterial components and oxidized lipoproteins, linking innate immune recognition with metabolic regulation.\u003cbr\u003e\u003cbr\u003eThe SCARA5 gene is located on chromosome 8p21.1 and is highly expressed in kidney, lung, and heart. SCARA5 localizes to the plasma membrane and endocytic vesicles, facilitating internalization of ferritin and other ligands. It contributes to maintaining iron homeostasis and protecting tissues from oxidative stress caused by excess free iron.\u003cbr\u003e\u003cbr\u003ePathologically, downregulation of SCARA5 expression has been reported in several cancers, including hepatocellular and renal carcinoma, suggesting a tumor suppressive role. By controlling iron uptake and reactive oxygen species balance, SCARA5 helps limit oxidative damage and cell proliferation. Research using SCARA5 antibody aids in studying iron metabolism, scavenger receptor function, and innate immunity.\u003cbr\u003e\u003cbr\u003eSCARA5 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect receptor expression in tissues and cells. \u003cbr\u003e\u003cbr\u003eStructurally, Scavenger receptor class A member 5 features a collagenous triple-helical domain that promotes trimerization and ligand binding, resembling other scavenger receptor family members. This antibody enables analysis of SCARA5�s contribution to innate immunity, oxidative stress defense, and cancer suppression.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SCARA5 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SCARA5 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SCARA5 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SCARA5 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SCARA5+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047312187757,"sku":"FY13109","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d788ca1a-c8fd-48aa-8121-1c41387be6b8.jpg?v=1782237103","url":"https:\/\/www.ebiohippo.com\/products\/scara5-antibody-scavenger-receptor-class-a-member-5-bha17136011","provider":"BioHippo","version":"1.0","type":"link"}