{"product_id":"scc-9-cell-bhc11101508","title":"SCC-9 cell","description":"SCC-9 is a human oral squamous cell carcinoma (OSCC) cell line commonly used in research focused on head and neck cancers, particularly in studying tumor progression, apoptosis, and treatment efficacy. OSCC is a prevalent form of head and neck cancer with a low 5-year survival rate, making cell lines like SCC-9 essential for understanding cancer biology and exploring potential therapeutic strategies.\nSCC-9 cells have been utilized in studies to assess the effects of various chemotherapeutic agents and natural compounds on oral cancer. For example, quercetin, a dietary flavonoid, has been shown to induce both necrosis and apoptosis in SCC-9 cells in a time- and dose-dependent manner. Quercetin’s antiproliferative effects were linked to the inhibition of thymidylate synthase, a key enzyme in DNA synthesis, leading to S-phase arrest in the cell cycle. The induction of necrosis was observed early, while prolonged exposure led to apoptosis through caspase-3 activation. Similarly, curcumin has been demonstrated to inhibit SCC-9 cell proliferation by regulating miR-9 expression, a microRNA associated with tumor suppression. Curcumin suppresses the Wnt\/β-catenin signaling pathway, thereby reducing the levels of key oncogenic factors like cyclin D1.\nThese findings highlight the relevance of SCC-9 cells in testing novel anticancer agents and unraveling the molecular mechanisms of OSCC development, particularly in targeting pathways like Wnt\/β-catenin and assessing the role of apoptosis and cell cycle regulation.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101508\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950223585645,"sku":"305390","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SCC-9_20WaKo_20P1_2010x01_20270924_ch00_1920x1920_d785383c-428a-4caa-a7ba-77a170fdd5aa.jpg?v=1769069216","url":"https:\/\/www.ebiohippo.com\/products\/scc-9-cell-bhc11101508","provider":"BioHippo","version":"1.0","type":"link"}