{"product_id":"scn1b-antibody-sodium-channel-subunit-beta-1-bha17128182","title":"SCN1B Antibody \/ Sodium channel subunit beta-1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eSCN1B Antibody \/ Sodium channel subunit beta-1 is an antibody targeting \u003cstrong\u003eSCN1B\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SCN1B.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human, Mouse.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, IHC-P, FACS (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eSodium channel subunit beta-1 (SCN1B) is a protein that is essential for the proper functioning of sodium channels in our cells. Sodium channels are responsible for the movement of sodium ions across cell membranes, playing a vital role in regulating cell excitability and communication. SCN1B is one of several subunits that work together to form functional sodium channels, with each subunit contributing to the overall activity and properties of the channel. One of the key roles of SCN1B is to modulate the activity of sodium channels, influencing their opening and closing dynamics. This modulation is crucial for controlling the flow of sodium ions into cells, which is essential for proper nerve signaling and muscle function. In addition to its role in regulating sodium channel activity, SCN1B also helps to stabilize the structure of sodium channels and promote their trafficking to the cell membrane. Research has shown that mutations in the SCN1B gene can lead to disruptions in sodium channel function, resulting in a variety of neurological and cardiovascular disorders. For example, mutations in SCN1B have been linked to epilepsy, as well as arrhythmias and heart failure.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eImmunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eFlow cytometry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q07699 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q07699 - Gene search: SCN1B — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SCN1B - Ensembl search: SCN1B — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SCN1B - PubMed search: SCN1B antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SCN1B+antibody - Reactome search: SCN1B — Reactome — https:\/\/reactome.org\/content\/query?q=SCN1B --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046410051949,"sku":"F55119-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046473490797,"sku":"F55119-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_151d2e49-3dc7-45c8-aec3-28407091c0db.jpg?v=1772000497","url":"https:\/\/www.ebiohippo.com\/products\/scn1b-antibody-sodium-channel-subunit-beta-1-bha17128182","provider":"BioHippo","version":"1.0","type":"link"}