{"product_id":"sco2-antibody-copper-chaperone-sco2-bha17136197","title":"SCO2 Antibody \/ Copper chaperone SCO2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSCO2 Antibody \/ Copper chaperone SCO2 is a anti-SCO2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SCO2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSCO2 antibody detects the Copper chaperone SCO2, a mitochondrial inner membrane protein required for the assembly of cytochrome c oxidase (complex IV) of the respiratory chain. The SCO2 gene encodes a metallochaperone that facilitates copper delivery to the COX2 subunit of cytochrome c oxidase, ensuring proper enzyme maturation and electron transport. SCO2 plays an essential role in aerobic energy metabolism, and its deficiency leads to mitochondrial dysfunction and severe metabolic disorders.\u003cbr\u003e\u003cbr\u003eLocated on chromosome 22q13.33, SCO2 (Synthesis of Cytochrome c Oxidase 2) is one of two homologous human SCO genes, the other being SCO1. Both are nuclear-encoded but localized to mitochondria, where they coordinate copper homeostasis. SCO2 binds copper ions via conserved cysteine and histidine residues and transfers them to cytochrome oxidase subunits through direct protein-protein interactions. Mutations in SCO2 disrupt this process and result in cytochrome c oxidase deficiency, leading to diseases such as fatal infantile cardioencephalomyopathy and Leigh-like syndrome.\u003cbr\u003e\u003cbr\u003eSCO2 expression is regulated by hypoxia and cellular copper status. Under low oxygen conditions, transcription factor HIF-1 may influence SCO2 expression to modulate oxidative phosphorylation efficiency. The protein is also involved in maintaining redox balance and preventing the accumulation of reactive oxygen species (ROS) within mitochondria. Beyond its role in energy production, SCO2 contributes to cellular copper distribution and may participate in signaling pathways that coordinate mitochondrial biogenesis.\u003cbr\u003e\u003cbr\u003eImmunohistochemical analysis using SCO2 antibody demonstrates mitochondrial localization in heart, skeletal muscle, and brain tissues, consistent with its role in energy metabolism. The antibody serves as a key tool for studying mitochondrial function, copper metabolism, and respiratory chain biogenesis. SCO2 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SCO2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SCO2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SCO2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SCO2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SCO2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047322476909,"sku":"FY13295","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_0b5646ac-135d-4c27-8e58-cf2c62acc005.jpg?v=1782237105","url":"https:\/\/www.ebiohippo.com\/products\/sco2-antibody-copper-chaperone-sco2-bha17136197","provider":"BioHippo","version":"1.0","type":"link"}