{"product_id":"sdhc-antibody-succinate-dehydrogenase-complex-subunit-c-bha17135228","title":"SDHC Antibody \/ Succinate dehydrogenase complex subunit C","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSDHC Antibody \/ Succinate dehydrogenase complex subunit C is a anti-SDHC Rabbit antibody Recombinant Rabbit Monoclonal clone 32S26 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SDHC\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32S26, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSDHC antibody is designed to detect succinate dehydrogenase complex subunit C, a critical component of both the mitochondrial respiratory chain and the tricarboxylic acid (TCA) cycle. SDHC is one of the four subunits of succinate dehydrogenase (complex II), which catalyzes the oxidation of succinate to fumarate in the TCA cycle while transferring electrons to the ubiquinone pool in the electron transport chain. This dual function makes SDHC a central player in cellular energy production, linking metabolic pathways to oxidative phosphorylation.\u003cbr\u003e\u003cbr\u003eSDHC antibody is widely used in studies of mitochondrial biology, cancer research, and metabolic disorders. Mutations in the SDHC gene are associated with hereditary paragangliomas and pheochromocytomas, tumors that arise from defects in mitochondrial function. Detecting SDHC expression with specific antibodies allows researchers to explore the molecular basis of these diseases and evaluate potential diagnostic markers.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, SDHC antibody specifically recognizes the SDHC protein band, providing accurate analysis of expression levels. In immunohistochemistry, it highlights mitochondrial localization patterns within tissue sections, while immunofluorescence reveals subcellular distribution in cultured cells. These applications make SDHC antibody versatile for both basic and translational research.\u003cbr\u003e\u003cbr\u003eSDHC plays an essential role in linking the TCA cycle to oxidative phosphorylation. Disruption of SDHC function impairs both energy production and reactive oxygen species regulation, contributing to tumorigenesis and metabolic disease. Studies employing SDHC antibody provide insights into how alterations in complex II activity influence cancer metabolism, oxidative stress, and cell survival.\u003cbr\u003e\u003cbr\u003eBeyond oncology, SDHC antibody is valuable for investigating mitochondrial disorders, neurodegeneration, and cardiovascular diseases. Complex II dysfunction contributes to pathologies ranging from Leigh syndrome to ischemia-reperfusion injury, making SDHC an important focus of mitochondrial research. By detecting SDHC expression, researchers can evaluate mitochondrial integrity and assess therapeutic strategies aimed at restoring respiratory function.\u003cbr\u003e\u003cbr\u003eSDHC antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SDHC - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SDHC - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SDHC - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SDHC - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SDHC+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047284793709,"sku":"FY12325","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_98306046-357b-4d68-b2de-09d63fce5979.jpg?v=1772019282","url":"https:\/\/www.ebiohippo.com\/products\/sdhc-antibody-succinate-dehydrogenase-complex-subunit-c-bha17135228","provider":"BioHippo","version":"1.0","type":"link"}