{"product_id":"sec14l2-antibody-sec14-like-protein-2-bha17136075","title":"SEC14L2 Antibody \/ SEC14-like protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSEC14L2 Antibody \/ SEC14-like protein 2 is a anti-SEC14L2 Rabbit antibody Recombinant Rabbit Monoclonal clone 31S32 supplied in Liquid format. Recommended for workflows such as Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SEC14L2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31S32, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IF, IHC, ICC, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSEC14L2 antibody detects SEC14 like protein 2, encoded by the SEC14L2 gene. SEC14 like protein 2 is a member of the SEC14 family of lipid binding proteins that regulate lipid metabolism, transport, and signaling. Originally identified by its homology to the yeast SEC14 phosphatidylinositol transfer protein, SEC14 like protein 2 binds lipids and may modulate phosphoinositide signaling in mammalian cells. SEC14L2 antibody provides researchers with a useful tool to study lipid biology, hepatocyte function, and metabolic regulation.\u003cbr\u003e\u003cbr\u003eSEC14 like protein 2 is primarily expressed in the liver, where it localizes to cytoplasmic and membrane compartments. Research using SEC14L2 antibody has demonstrated that it interacts with phosphatidylinositol and other lipids, potentially regulating availability of signaling molecules. In hepatocytes, SEC14 like protein 2 may act as a cofactor for lipid modifying enzymes, integrating lipid metabolism with cell signaling and homeostasis. Its conservation across species highlights an essential role in cellular lipid handling.\u003cbr\u003e\u003cbr\u003eOne of the most intriguing functions of SEC14 like protein 2 is its ability to support hepatitis C virus replication. Studies with SEC14L2 antibody have shown that expression of this protein allows hepatitis C virus to replicate efficiently in cell culture models that are otherwise nonpermissive. This has made SEC14 like protein 2 a focus of viral research, as its presence facilitates the assembly of viral replication complexes. Its role in host-virus interactions positions it as a potential antiviral target.\u003cbr\u003e\u003cbr\u003eBeyond virology, SEC14 like protein 2 is associated with cancer biology and metabolic disease. Research using SEC14L2 antibody has suggested that altered expression influences lipid signaling pathways, contributing to tumorigenesis or metabolic dysfunction. Because lipid metabolism is tightly linked to growth control and energy balance, SEC14 like protein 2 may serve as a metabolic regulator in both health and disease.\u003cbr\u003e\u003cbr\u003eSEC14L2 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting confirms expression in liver tissues and cell lines, immunohistochemistry demonstrates tissue distribution, and immunofluorescence reveals cytoplasmic and membrane localization. These applications make SEC14L2 antibody versatile for metabolic and viral research.\u003cbr\u003e\u003cbr\u003eBy supplying validated SEC14L2 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SEC14L2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SEC14L2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SEC14L2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SEC14L2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SEC14L2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047314415981,"sku":"FY13173","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9eaa3bdb-4ef2-4742-bfc9-1305ed5967c9.jpg?v=1772019403","url":"https:\/\/www.ebiohippo.com\/products\/sec14l2-antibody-sec14-like-protein-2-bha17136075","provider":"BioHippo","version":"1.0","type":"link"}