{"product_id":"sec62-antibody-translocation-protein-sec62-bha17136226","title":"SEC62 Antibody \/ Translocation protein SEC62","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSEC62 Antibody \/ Translocation protein SEC62 is a anti-SEC62 Rabbit antibody Recombinant Rabbit Monoclonal clone 31S64 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SEC62\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31S64, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSEC62 antibody detects Translocation protein SEC62, encoded by the SEC62 gene. Translocation protein SEC62 is an endoplasmic reticulum membrane protein that functions as part of the SEC61-SEC62-SEC63 complex required for posttranslational translocation of proteins into the endoplasmic reticulum. SEC62 antibody provides researchers with a specific reagent for investigating protein translocation, endoplasmic reticulum biology, and disease processes associated with protein trafficking.\u003cbr\u003e\u003cbr\u003eTranslocation protein SEC62 cooperates with the SEC61 channel and SEC63 cochaperone to mediate insertion of polypeptides into the endoplasmic reticulum lumen. Research using SEC62 antibody has shown that it functions particularly in the import of short signal peptide proteins and stress-inducible proteins. This activity helps maintain proteostasis under conditions of cellular stress, ensuring that unfolded or newly synthesized proteins are efficiently imported and processed.\u003cbr\u003e\u003cbr\u003eStudies with SEC62 antibody have revealed that the protein also contributes to the unfolded protein response and endoplasmic reticulum stress adaptation. By regulating the influx of client proteins, Translocation protein SEC62 limits accumulation of misfolded proteins and protects cells from apoptosis. These findings underscore its protective role in maintaining endoplasmic reticulum homeostasis.\u003cbr\u003e\u003cbr\u003eIn cancer biology, overexpression of SEC62 has been identified in lung, prostate, and thyroid cancers. Research using SEC62 antibody has demonstrated that elevated expression enhances stress tolerance, migration, and invasion, linking the protein to aggressive tumor phenotypes. Because of these properties, SEC62 is being explored as a prognostic biomarker and therapeutic target in oncology.\u003cbr\u003e\u003cbr\u003eSEC62 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects SEC62 expression under stress conditions, immunohistochemistry highlights localization to the endoplasmic reticulum in tissues, and immunofluorescence shows its membrane association with endoplasmic reticulum structures. These applications make SEC62 antibody an important reagent in cell biology and disease research.\u003cbr\u003e\u003cbr\u003eBy supplying validated SEC62 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SEC62 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SEC62 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SEC62 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SEC62 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SEC62+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047322378605,"sku":"FY13324","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c829887d-add7-45d8-bf1f-a315e58a3c38.jpg?v=1772019428","url":"https:\/\/www.ebiohippo.com\/products\/sec62-antibody-translocation-protein-sec62-bha17136226","provider":"BioHippo","version":"1.0","type":"link"}