{"product_id":"sell-antibody-l-selectin-lam-1-bha17128142","title":"SELL Antibody \/ L-Selectin \/ LAM-1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eSELL Antibody \/ L-Selectin \/ LAM-1 is an antibody targeting \u003cstrong\u003eSELL\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SELL.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, IHC-P, FACS (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eL-Selectin, also known as CD62L, SELL and LAM-1, is a cell adhesion molecule found on the surface of leukocytes, or white blood cells. It plays a role in the immune response by facilitating the binding of leukocytes to endothelial cells in the blood vessels, allowing them to migrate to sites of infection or inflammation. One of the key functions of L-Selectin is its involvement in the process of leukocyte rolling. When an infection or injury occurs, inflammatory signals are released that trigger the expression of adhesion molecules on the surface of endothelial cells. L-Selectin on leukocytes then binds to its ligands on the endothelial cells, causing the leukocytes to roll along the vessel wall. This rolling motion slows down the leukocytes and allows them to survey the endothelial surface for signs of infection. Once the leukocytes have identified the site of infection, they can firmly adhere to the endothelial cells and extravasate, or migrate, into the surrounding tissue. L-Selectin plays a critical role in this step by mediating the initial interaction between leukocytes and endothelial cells. Without L-Selectin, leukocytes would not be able to efficiently migrate to the site of infection, impairing the immune response. \u003cbr\u003eIn addition to its role in leukocyte trafficking, L-Selectin also plays a role in regulating the activation and function of leukocytes. Studies have shown that L-Selectin signaling can modulate the production of cytokines and chemokines, which are key mediators of inflammation. By influencing the inflammatory response, L-Selectin can help regulate the magnitude and duration of immune reactions, preventing excessive tissue damage. Furthermore, L-Selectin has been implicated in a variety of inflammatory and autoimmune diseases. Dysregulation of L-Selectin expression or function can lead to abnormal leukocyte trafficking and contribute to chronic inflammation. Understanding the role of L-Selectin in these conditions may provide insights into potential therapeutic targets for treating inflammatory diseases.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eImmunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eFlow cytometry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry P14151 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P14151 - Gene search: SELL — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SELL - Ensembl search: SELL — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SELL - PubMed search: SELL antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SELL+antibody - Reactome search: SELL — Reactome — https:\/\/reactome.org\/content\/query?q=SELL --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.05 ml","offer_id":53046408675693,"sku":"F55079-0.05ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.2 ml","offer_id":53046469755245,"sku":"F55079-0.2ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_926f6196-fad2-4963-a287-679b7ce0fd2c.jpg?v=1772000496","url":"https:\/\/www.ebiohippo.com\/products\/sell-antibody-l-selectin-lam-1-bha17128142","provider":"BioHippo","version":"1.0","type":"link"}