{"product_id":"septin8-antibody-septin-8-bha17136165","title":"SEPTIN8 Antibody \/ Septin 8","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSEPTIN8 Antibody \/ Septin 8 is a anti-SEPTIN8 Rabbit antibody Recombinant Rabbit Monoclonal clone 30S14 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SEPTIN8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30S14, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, IP, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSEPTIN8 antibody detects Septin 8, encoded by the SEPTIN8 gene. Septin 8 is a member of the septin family of GTP binding cytoskeletal proteins involved in cytokinesis, vesicle trafficking, and cellular morphogenesis. SEPTIN8 antibody provides researchers with a specific reagent to study cytoskeletal organization, cell division, and neuronal development.\u003cbr\u003e\u003cbr\u003eSeptins form hetero oligomeric complexes that polymerize into filaments and higher order structures. Research using SEPTIN8 antibody has shown that Septin 8 contributes to filament assembly, acting as a structural scaffold at the plasma membrane and division sites. Septin complexes coordinate with actin and microtubules to regulate cell polarity and compartmentalization, ensuring proper cell division and morphogenesis.\u003cbr\u003e\u003cbr\u003eIn neurons, Septin 8 plays roles in dendritic branching and synapse formation. Studies with SEPTIN8 antibody have demonstrated that it localizes to dendritic spines and regulates cytoskeletal rearrangements required for synaptic plasticity. Dysregulation of Septin 8 expression or function may impair neural connectivity and contribute to neurological disorders.\u003cbr\u003e\u003cbr\u003eSeptin dysregulation has been linked to cancer and neurodegeneration. Research using SEPTIN8 antibody has revealed that abnormal expression influences cell cycle progression, apoptosis, and tumor growth. In the nervous system, altered Septin 8 activity has been associated with psychiatric and developmental disorders, reflecting its importance in synaptic regulation and cytoskeletal dynamics.\u003cbr\u003e\u003cbr\u003eSEPTIN8 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting identifies endogenous protein levels, immunohistochemistry highlights expression in proliferative tissues, and immunofluorescence demonstrates cytoskeletal localization. These applications make SEPTIN8 antibody a versatile reagent in cytoskeletal and neuronal research.\u003cbr\u003e\u003cbr\u003eBy supplying validated SEPTIN8 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SEPTIN8 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SEPTIN8 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SEPTIN8 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SEPTIN8 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SEPTIN8+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047319593325,"sku":"FY13263","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a7adbd49-46da-4a03-8d9e-f180486f33a4.jpg?v=1772019417","url":"https:\/\/www.ebiohippo.com\/products\/septin8-antibody-septin-8-bha17136165","provider":"BioHippo","version":"1.0","type":"link"}