{"product_id":"set07-antibody-kmt5a-bha17100180","title":"SET07 Antibody \/ KMT5A","description":"\u003cp\u003eSET07 is a protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53\/TP53 at 'Lys-382', leading to repress p53\/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. [UniProt]\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53042862063981,"sku":"F40198-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53042945327469,"sku":"F40198-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9f07004e-054b-4696-ab74-61cd31b37beb.jpg?v=1771923613","url":"https:\/\/www.ebiohippo.com\/products\/set07-antibody-kmt5a-bha17100180","provider":"BioHippo","version":"1.0","type":"link"}