{"product_id":"sgcb-antibody-beta-sarcoglycan-bha17135345","title":"SGCB Antibody \/ Beta Sarcoglycan","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSGCB Antibody \/ Beta Sarcoglycan is a anti-SGCB Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SGCB\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSGCB antibody recognizes Beta sarcoglycan, a transmembrane glycoprotein that forms part of the dystrophin-associated glycoprotein complex (DGC) in muscle cells. This complex stabilizes the sarcolemma and links the cytoskeleton to the extracellular matrix. The SGCB gene encodes the beta subunit of the sarcoglycan complex, which also includes alpha, gamma, and delta sarcoglycans. Mutations in SGCB cause limb-girdle muscular dystrophy type 2E (LGMD2E), characterized by progressive muscle weakness and degeneration. The SGCB antibody is used extensively in muscular dystrophy research, enabling analysis of sarcoglycan expression, localization, and pathological loss in patient samples and model systems.\u003cbr\u003e\u003cbr\u003eBeta sarcoglycan is a 318-amino acid membrane protein encoded on human chromosome 4q12. It contains a large extracellular domain with multiple N-glycosylation sites, a single transmembrane segment, and a short cytoplasmic tail. Proper assembly of the sarcoglycan complex is essential for maintaining membrane integrity during muscle contraction. Loss or misfolding of any component can destabilize the complex and lead to muscle fiber damage. Immunohistochemistry with SGCB antibody reveals strong sarcolemmal staining in normal skeletal and cardiac muscle, whereas dystrophic samples often show complete or partial absence of the protein.\u003cbr\u003e\u003cbr\u003eThe SGCB antibody is valuable for diagnostic and mechanistic studies of muscular dystrophies. In western blot, beta sarcoglycan is typically detected at 43�45 kDa. Its expression patterns provide insights into disease progression, compensatory mechanisms, and the effectiveness of gene replacement therapies. Research has shown that restoring SGCB expression in animal models can reassemble the DGC and improve muscle function, highlighting its potential as a therapeutic target. Moreover, beta sarcoglycan plays roles in cardiomyocyte adhesion and signal transduction, extending its relevance beyond skeletal muscle.\u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SGCB - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SGCB - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SGCB - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SGCB - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SGCB+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047286858093,"sku":"FY12442","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_3dbe0f5d-9349-44c3-b5d2-887e546ba1d9.jpg?v=1782237004","url":"https:\/\/www.ebiohippo.com\/products\/sgcb-antibody-beta-sarcoglycan-bha17135345","provider":"BioHippo","version":"1.0","type":"link"}