{"product_id":"sgcz-antibody-sarcoglycan-zeta-bha17136177","title":"SGCZ Antibody \/ Sarcoglycan zeta","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSGCZ Antibody \/ Sarcoglycan zeta is a anti-SGCZ Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SGCZ\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSGCZ antibody detects Sarcoglycan zeta, a transmembrane glycoprotein that forms part of the sarcoglycan complex within the dystrophin-associated glycoprotein complex (DGC). The UniProt recommended name is Sarcoglycan zeta (SGCZ). This protein contributes to the mechanical stability of muscle cell membranes and signal transduction between the extracellular matrix and cytoskeleton.\u003cbr\u003e\u003cbr\u003eFunctionally, SGCZ antibody identifies a 243-amino-acid single-pass membrane protein primarily expressed in skeletal and cardiac muscle. SGCZ associates with alpha-, beta-, gamma-, and delta-sarcoglycans to form a heterotetrameric complex that links dystrophin to the sarcolemma. This interaction is critical for maintaining membrane integrity during muscle contraction and relaxation cycles. SGCZ also participates in intracellular signaling that regulates calcium handling and muscle fiber repair.\u003cbr\u003e\u003cbr\u003eThe SGCZ gene is located on chromosome 8p22 and is expressed in skeletal muscle, heart, and smooth muscle tissues. Its transcription is regulated by myogenic factors including MYOD1 and MEF2, aligning expression with muscle differentiation and regeneration. SGCZ contributes to muscle architecture by connecting the cytoskeleton to the extracellular matrix through dystrophin and laminin interactions.\u003cbr\u003e\u003cbr\u003ePathologically, mutations in SGCZ cause limb-girdle muscular dystrophy type 2C-related phenotypes and contribute to sarcoglycanopathy spectrum disorders. Deficiency leads to sarcolemma fragility, fiber necrosis, and progressive muscle weakness. Reduced expression has also been observed in cardiomyopathies, where it contributes to cardiac dysfunction. Research using SGCZ antibody supports studies in muscle disease, sarcolemma structure, and dystrophin complex biology.\u003cbr\u003e\u003cbr\u003eSGCZ antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect membrane glycoproteins in muscle tissue. \u003cbr\u003e\u003cbr\u003eStructurally, Sarcoglycan zeta contains an extracellular glycosylated domain and a short cytoplasmic tail anchoring it to the dystrophin-associated complex. It interacts directly with beta- and delta-sarcoglycans and indirectly stabilizes dystrophin. This antibody facilitates exploration of SGCZ's role in muscle membrane integrity, mechanical signaling, and dystrophic pathology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SGCZ - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SGCZ - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SGCZ - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SGCZ - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SGCZ+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047320576365,"sku":"FY13275","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2714cf5a-777d-485d-9350-8cfb1197b1e2.jpg?v=1782237101","url":"https:\/\/www.ebiohippo.com\/products\/sgcz-antibody-sarcoglycan-zeta-bha17136177","provider":"BioHippo","version":"1.0","type":"link"}