{"product_id":"shd-antibody-sh2-domain-containing-adapter-protein-d-bha17135816","title":"SHD Antibody \/ SH2 domain-containing adapter protein D","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSHD Antibody \/ SH2 domain-containing adapter protein D is a anti-SHD Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SHD\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSHD antibody detects SH2 domain-containing adapter protein D, a cytoplasmic adaptor molecule that transduces tyrosine kinase signals controlling cell differentiation, immune activation, and neuronal development. Encoded by the SHD gene on chromosome 4q28.1, this protein contains an SH2 (Src homology 2) domain that recognizes phosphotyrosine motifs and mediates protein-protein interactions within intracellular signaling cascades. SHD acts as a linker between activated receptors and downstream signaling enzymes, contributing to signal amplification and specificity.\u003cbr\u003e\u003cbr\u003eStructurally, SHD is a 440-amino-acid protein of approximately 48 kilodaltons featuring a central SH2 domain flanked by low-complexity regions that facilitate interaction with membrane receptors and signaling complexes. It localizes to the cytoplasm and plasma membrane following receptor activation and participates in pathways initiated by growth factors, cytokines, and immune receptors. Through its SH2-mediated binding, SHD recruits kinases and phosphatases that regulate phosphorylation dynamics and cellular response outcomes.\u003cbr\u003e\u003cbr\u003eThe SHD antibody is widely used in immunology, signal transduction, and neurobiology research to study SH2 domain-mediated signaling, receptor cross-talk, and cytoplasmic adaptor functions. Western blot analysis detects a 48 kilodalton band corresponding to SHD, while immunofluorescence shows diffuse cytoplasmic and membrane-associated staining. This antibody enables detailed examination of signaling network architecture and adaptor-mediated pathway modulation.\u003cbr\u003e\u003cbr\u003eFunctionally, SHD contributes to the organization of signaling complexes downstream of tyrosine kinases, facilitating rapid response to extracellular cues. It modulates pathways involving MAPK, JAK\/STAT, and PI3K signaling cascades, thereby influencing immune activation, synaptic development, and cell fate determination. Dysregulation of SHD expression may alter immune receptor signaling and neuronal differentiation, implicating the protein in both immunological and developmental disorders. The SHD antibody provides a valuable research tool for characterizing intracellular adaptor networks and phosphotyrosine-dependent signaling mechanisms.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SHD - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SHD - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SHD - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SHD - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SHD+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047305699693,"sku":"FY12914","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_afe28e7e-85f2-4262-ae66-429cc4074386.jpg?v=1772019402","url":"https:\/\/www.ebiohippo.com\/products\/shd-antibody-sh2-domain-containing-adapter-protein-d-bha17135816","provider":"BioHippo","version":"1.0","type":"link"}