{"product_id":"sheep-transferrin-bhp10506051","title":"Sheep transferrin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative sheep transferrin (TF) is purified from sheep serum and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Carrier Protein\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eTransferrin is a glycoprotein that binds ferric iron (Fe³⁺) with high affinity and transports it through blood and extracellular fluids. Cellular iron uptake commonly occurs via transferrin receptor–mediated endocytosis, linking transferrin biology to proliferation, metabolism, and stress responses.\u003c\/p\u003e\u003cp\u003eTransferrin concentration and total iron binding capacity (TIBC) are currently used to assess iron status. Although correlation between TIBC and transferrin is generally considered as good, conversion factors between the two analytes found in literature show large differences.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eIron homeostasis research intersecting with oxidative stress and ferroptosis, where iron availability and transport pathways are central.\u003c\/li\u003e \u003cli\u003eTransferrin receptor biology in cancer and immune cells as a window into nutrient uptake and activation states.\u003c\/li\u003e \u003cli\u003eGlycosylation and iron-loading state (apo vs holo) as variables influencing binding, trafficking, and assay readouts.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eReceptor-binding and uptake studies to probe transferrin receptor activity in cells and tissues.\u003c\/li\u003e \u003cli\u003eIron-binding\/transfer concepts in biochemical assays, including comparisons of apo- and holo-transferrin behaviors.\u003c\/li\u003e \u003cli\u003eCalibration\/controls for immunoassays and proteomics where transferrin is a common high-abundance plasma protein.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eIron saturation state strongly affects transferrin’s biochemical behavior; interpret results in light of apo\/holo mixtures.\u003c\/li\u003e \u003cli\u003eAs a glycoprotein, transferrin may present glycoform heterogeneity; native preparations can reflect source-dependent variation.\u003c\/li\u003e \u003cli\u003eSpecies differences and plasma-derived co-factors can influence receptor interactions; align the reagent with your experimental model.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=transferrin TF - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=transferrin TF - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=transferrin TF%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"10 mg","offer_id":53052975645037,"sku":"CSB-NP008601sh-10MG","price":3605.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052975677805,"sku":"CSB-NP008601sh-1MG","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP008601sh-SDS.jpg?v=1772166487","url":"https:\/\/www.ebiohippo.com\/products\/sheep-transferrin-bhp10506051","provider":"BioHippo","version":"1.0","type":"link"}