{"product_id":"sin-nombre-virus-glycoprotein-bhp20900070","title":"Sin Nombre Virus Glycoprotein (GnΔTM)","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eSin Nombre Virus (SNV) is a New World hantavirus and the principal etiologic agent of Hantavirus Pulmonary Syndrome (HPS) in North America, first identified during a 1993 outbreak in the U.S. Southwest. SNV is transmitted to humans through aerosolized excreta of infected deer mice (\u003cem\u003ePeromyscus maniculatus\u003c\/em\u003e). The Gn glycoprotein is the major surface envelope protein of hantaviruses, forming heterodimeric complexes with Gc on the virion surface. Gn mediates receptor binding via β3 integrins, drives viral entry, and is the primary target of neutralizing antibodies. Its conservation across hantavirus strains makes SNV Gn a critical antigen for serodiagnosis, epidemiological surveillance, and hantavirus vaccine research.\u003c\/p\u003e\n\u003ch2\u003eProduct Description\u003c\/h2\u003e\n\u003cp\u003e\u003cspan class=\"bhp-cat-pill\"\u003eHantavirus\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eThis recombinant Sin Nombre Virus Glycoprotein (Gn) minus the transmembrane domain (SNVGnΔTM) is a HIS-tagged protein produced in mammalian cells and purified by FPLC. Supplied as purified liquid protein in formulation buffer.\u003c\/p\u003e\n\u003ch2\u003eProtein Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eCatalog Number\u003c\/th\u003e\n\u003ctd\u003e0517-001\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFull Name\u003c\/th\u003e\n\u003ctd\u003eRecombinant Sin Nombre Virus Glycoprotein (Gn) minus the Transmembrane Domain (SNVGnΔTM)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAbbreviation\u003c\/th\u003e\n\u003ctd\u003eSNV GnΔTM\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eTarget\u003c\/th\u003e\n\u003ctd\u003eSin Nombre Virus Gn Glycoprotein (ΔTM)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eTarget Pathogen\u003c\/th\u003e\n\u003ctd\u003eSin Nombre Virus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eProduct Category\u003c\/th\u003e\n\u003ctd\u003eHantavirus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eExpression System\u003c\/th\u003e\n\u003ctd\u003eMammalian Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurification\u003c\/th\u003e\n\u003ctd\u003eFPLC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eTag\u003c\/th\u003e\n\u003ctd\u003eHIS-tag (C-terminus)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFormulation\u003c\/th\u003e\n\u003ctd\u003e20 mM TrisHCl pH 8, 0.15 M NaCl, 5% Sucrose\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eApplications\u003c\/th\u003e\n\u003ctd\u003eELISA, Western Blot\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003e-20°C for 1 week; -80°C for long-term storage.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eFunctional Activity\u003c\/h2\u003e\n\u003cp\u003eSNVGnΔTM has been validated by capture ELISA and Western Blot. In a capture ELISA, SNVGnΔTM was coated at 2 µg\/mL in PBS and detected with a mouse anti-Sin Nombre Virus GP polyclonal antibody (IBT Cat# 0309-001), demonstrating a specific dose-response. SDS-PAGE analysis confirms protein integrity under denaturing and reducing conditions; Western Blot detection was performed using anti-HIS antibody at 1:1000 dilution.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\n\u003cstrong\u003eResearch Use Only (RUO).\u003c\/strong\u003e Not approved for human or veterinary use. Handle according to institutional biosafety guidelines. Commercial use requires written approval from Integrated BioTherapeutics, LLC.\u003c\/div\u003e\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eExplore additional IBT Bioservices hantavirus and filovirus antigens available through BioHippo.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"IBT Bioservices","offers":[{"title":"100 ug","offer_id":53402626851181,"sku":"0517-001","price":600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Group-2106.png?v=1780508214","url":"https:\/\/www.ebiohippo.com\/products\/sin-nombre-virus-glycoprotein-bhp20900070","provider":"BioHippo","version":"1.0","type":"link"}