{"product_id":"sk-ut-1-cell-bhc11100767","title":"SK-UT-1 cell","description":"The SK-UT-1 cell line is derived from human uterine leiomyosarcoma (ULMS), a highly aggressive form of cancer originating in the smooth muscle of the uterus. This cell line is a key model for studying tumorigenesis, metastasis, and drug resistance in ULMS. SK-UT-1 cells exhibit features of sarcomas, including rapid proliferation, poor differentiation, and resistance to conventional therapies. In particular, they are used to investigate cancer stem-like cells (CSCs), which play a significant role in cancer recurrence and resistance to chemotherapy. Research has identified a subpopulation of CD133+ CSCs within SK-UT-1 cells, which demonstrate enhanced self-renewal, colony formation, and resistance to apoptosis.\nStudies using SK-UT-1 have focused on characterizing the CD133+ CSCs, revealing their ability to form tumorspheres, a feature indicative of stem cell-like behavior. This subpopulation shows increased tumorigenic potential in vivo, where even a small number of cells (104) are sufficient to initiate tumor formation in xenograft models. The CD133+ cells exhibit resistance to chemotherapeutic agents such as doxorubicin, which further supports their role in therapy resistance. Additionally, elevated levels of CSC-related markers, including CD44, ALDH1, and BMI1, were found in CD133+ cells compared to their CD133− counterparts, confirming their role as cancer stem cells.\nSK-UT-1 cells have become a vital tool in understanding ULMS progression and in developing potential therapeutic strategies. Targeting the CD133+ cancer stem-like cell population within these tumors may offer a promising approach to improve outcomes in patients with ULMS by addressing the root causes of metastasis and chemoresistance.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100767\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950224634221,"sku":"300455","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SK-UT-1_20P1_2010x01_20210825_ch00_1920x1920_e59da85f-f296-4dfa-8408-7e5f11c162eb.jpg?v=1769069230","url":"https:\/\/www.ebiohippo.com\/products\/sk-ut-1-cell-bhc11100767","provider":"BioHippo","version":"1.0","type":"link"}