{"product_id":"skw-3-cell-bhc11100658","title":"SKW-3 cell","description":"The SKW-3 cell line, originally believed to be derived from the peripheral blood of a 61-year-old male diagnosed with chronic lymphocytic leukemia (CLL), represents a significant point of interest in cancer research, particularly in the study of B-cell leukemias. Over time, critical reassessments using Short Tandem Repeat (STR) profiling have illuminated an important issue-SKW-3 cells are not a pure line from the CLL patient, but are instead contaminated, now identified as a derivative of the KE-37 cell line. This revelation has profound implications for past research and future studies, emphasizing the need for rigorous cell line authentication to ensure experimental accuracy.\n\nKE-37, the true origin of the SKW-3 cells, is a B-cell line established from a patient with acute lymphoblastic leukemia (ALL). This shift in origin from CLL to ALL, due to the contamination, drastically alters the biological context and utility of the SKW-3 line. For researchers, this means that any findings or data previously attributed to CLL-specific mechanisms when using SKW-3 must be critically evaluated and potentially revised. The reclassification to a derivative of KE-37 necessitates a shift in the application of SKW-3 cells towards studies more relevant to ALL and its underlying mechanisms, rather than CLL.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100658\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950224732525,"sku":"300343","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SKW-3_P33_18.01.2016_20x_1_20-_20Copy_1920x1920_96d4a0d4-8506-4044-8ca4-dcfbbec5c414.jpg?v=1769069231","url":"https:\/\/www.ebiohippo.com\/products\/skw-3-cell-bhc11100658","provider":"BioHippo","version":"1.0","type":"link"}